Preliminary 2017 Poster List


Toxicity Profiling Using a Battery of Assays in Zebrafish Embryos Including Teratogenicity, Behavior, Cardiotoxicity, Ototoxicity and Hepatotoxicity

Bioneer AS

Neurons Derived from Isogenic IPS Cell Lines with Edited APOE Genotypes Display Differences in Mitochondrial Respiration

Boston Children's Hospital

Glycoceramide-Based Delivery of Biologics Across Epithelial Cell Barriers

Brown University

Advancing the Use of 3D Spheroids for Quantitative, Live-Cell, Confocal Microscopy in a High-Throughput Format


Validation of Human Blood-Brain Barrier from Pluripotent Stem Cells

Center of Molecular Immunology

Synergistic potentiation of the Anti-Metastatic Effect of Anti EGFR mAbs by its Combination with Immunotherapies Targeting the Ganglioside NGcGM3

Central University of Gujarat

Surface Chemistry of Hydrogel Modulates Microtumor Formation: Oxidised Dextran Based 3D Tumor Model for Drug Screening

Covenant University

Co-Administration of Artemisinin and Ricinodendron Heudelotii Leaf Extract: Effects on Certain Antioxidants and Liver Parameters in Male Wistar Rats


HepatoPearls: 3D Liver Micro-Tissues for High Throughput Drug-Drug Interaction Assays

Harvard Medical School

Determining the Role and Dynamics of the Zinc-Finger Transcription Factor SALL4 in AML Leukemogenesis Using Bioinformatics Tools

Harvard University

Design and Validation of Small Molecule Probes of Nrp2-Sema3f Signaling

Medical University of South Carolina

Peripherally-Restricted Orally-Active Kappa Opioid Agonist Analgesic: Pre-Clinical Findings

Midwestern University

Nanopharmaceutical Vitamin E Tocotrienols for Chemo-Sensitization of Tumor Cells

Midwestern University

Optimized Decoy Recombinant CD47 for Effective Mitigation of Thrombosppondin 1-Induced Vascular Dysfunctions: a Mechanistic Study

Newcastle University

Investigating the Brain in Mouse Models for Duchenne Muscular Dystrophy

Northeastern University

Magnetic Targeting of Rosette Nanotube-Coated Iron Oxide Nanoparticles for the Treatment of Pancreatic Cancer

Politecnico di Milano

Human Organotypic Model of a Bone Perivascular Niche for the Study of Breast Cancer Dissemination

SUNY Polytechnic Institute

Metal Filled Carbon Nanotubes for Targeted Therapy: a Feasibility Study

Tsinghua University

Alignment-Free Method to Study Phylogeny of Marine Bacteria

University of Florida

RNA-Modified T Cell as a Platform to Deliver Immunomodulatory Agents to Brain Tumor

Uppsala University

Brain Regiona Drug Disposition

Yale University

The Use of a Truncated Epidermal Growth Factor Receptor (EGFRt) as a Safety Switch For Chimeric Antigen Receptor (CAR)-T-Cell Immunotherapy

Poster List from World Preclinical Congress 2016

  • ACEA Biosciences, Inc. - Assessment of the Electromechanical Window of Human IPSC-Derived Cardiomyocytes and its Modulation by Compounds Affecting Cardiac Function
  • ACEA Biosciences, Inc. - Evaluation of Acute and Chronic Effects of Kinase Inhibitors on Electrical and Contractile Activity of Human iPSC-Derived Cardiomyocytes
  • ACEA Biosciences, Inc. - Simultaneous Measurement of Excitation-Contraction Coupling of iPSC-Derived Cardiomyocytes for Cardiac Disease Modeling and Risk Assessment
  • ACEA Biosciences, Inc. - Using Impedance-Based Approaches for Measuring Cell-Mediated Cytotoxicity and Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC)
  • Alabama State University - Bioengineered 3D Skin with Encapsulated Interleukin-10 to Avoid Immune Rejection
  • Alabama State University - Development of 3D Wound Healing Model Using Natural Polymers
  • Alabama State University - Human 3D Skin Model Developed Using Alveotax Scaffold and Applications of Functionalized Silver CNT and Anti-Microbial Peptides
  • Alabama State University - Three-Dimensional Scaffolds Fabrication for Orthopedic Application
  • Amgen, Inc. - Lead Optimization in a Series of Aminooxazoline Xanthene BACE Inhibitors for the Treatment of Alzheimer's Disease
  • Applied StemCell, Inc. - Combined CRISPR - TARGATT™ Gene Editing Generates High Efficiency Knock-Out, Point Mutation and Large Fragment Knock-In in Human iPS Cells
  • Arizona State University - Imaging Mechanical Waves That Accompany Action Potential in Mammalian Neurons
  • Arizona State University - Quantification of Epidermal Growth Factor Receptor Expression Level and Binding Kinetics on Cell Surfaces by Surface Plasmon Resonance Imaging
  • Asthagiri Herbal Research Foundation - Fabrication of Smart Dual Drug Loaded Cationic Magnetic Nanocarrier for Treatment of Aggressive Breast Cancer
  • AXENIS SAS - Pre-Clinical Models for Innovative Medicine
  • Axiogenesis AG - Human iPSC-Derived Cardiomyocytes for HTS to Assess Acute Drug-Induced as Well as Chronic (Tyr Kinase Inhibitor) Cardiotoxicity
  • Axiogenesis AG - Monitoring and Adapting the Functional Phenotypic of Developing Human iPSC-Derived Neuronal Networks Using Multi-Variate Analysis of MEA Data
  • BellBrook Labs LLC - Determination of Drug Residence Times in a HTS Format Using Transcreener ADP2 Assay
  • Biogen - A Human 3D Microfluidic Cell Culture Model of the Blood-Brain Barrier to Study Barrier Function, Drug Penetration, and Leukocyte Trafficking
  • Bioven Europe - Outcomes of Assessing Combination of Anti -EGF Antibodies and TKI in PC9 Tumor Cells with EGFR Mutation
  • Boehringer Ingelheim - A Blinded Impedance-Based Preclinical Cardiac Safety/Tox Assessment Using Human iPSC-Derived Cardiomyocytes
  • Boston University - Integrated Platform for iPSC-Derived Cardiomyocyte Production to Enable Lead Discovery
  • Cellecta, Inc. - CRISPR/Cas9 Genome-Wide gRNA Library for Target Identification
  • Cellecta, Inc. - Driver-Map: Molecular Profiling of Tumor Microenvironment for Biomarker Discovery Using CancerNet
  • Charles River Laboratories - A Cell Based Assay to Identify Small Molecules That Stabilize Mutant Clarin
  • Charles River Laboratories - The Use of the Impedance Recording Technique to Gauge the Inotropic Responses of Human Induced Pluripotent Stem-Cell Derived Cardiomyocytes (HIPSC-CMS)
  • Cleave Biosciences - Utilization of K48-Ubiquitin Modulation as a Biomarker of Target Engagement of Protein Homeostasis Inhibitor in the Clinic: Preclinical Validation with CB-5083, the p97 First in Class Inhibitor
  • Cold Spring Harbor Laboratory - Molecular Basis for High-Affinity Zinc Inhibition in GluN1/GluN2A NMDA Receptors
  • Collaborative Drug Discovery, Inc. - CDD Vault: A Modern Approach for Drug Research Project Team Informatics
  • Collaborative Drug Discovery, Inc. - CDD Vision: A New Reactive Web Platform for Multidimensional Drug Discovery Data Mining and Visualization
  • Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF) - Identification of a Novel Peptide That Selectively Binds to Kidney Injury Molecule-1 (KIM-1) by Phage Displayed Peptide Library
  • Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF) - In Vivo Multimodal Imaging for the Evaluation of Anticancer Agents in Metastatic Breast Cancer Mouse Model
  • Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF) - The Evaluation of Therapeutic Macromolecular Drugs as an Anti-Cancer Drug Using BRET System
  • DiscoverX Corporation - Novel, Improved Cell-Based Assays to Enable Immunotherapy Drug Development for Checkpoint Receptors
  • DiscoverX Corporation - Phenotypic Profiling in BioMAP Human Primary Cell Systems Identifies a Tox Alert Signature for Skin Irritation
  • DiscoverX Corporation - Specifically Measure Target Cell Death in a Co-Culture with Immune Cells Through a Non-Radioactive, Dye-Free Cytotoxicity Assay
  • Duke-NUS Medical School - Generation of Human Embryonic Stem Cells-Derived Cells in Chemically Defined and Xeno-Free Systems on Laminin Matrices for Blood-Brain Barrier Modeling
  • Eisai Research Institute - Imaging Metabotropic Glutamate System to Facilitate Drug Development
  • Harvard Medical School - Crystal structure of human tetraspanin reveals a conserved cholesterol intramembrane binding cavity
  • Inovio Pharmaceuticals, Inc. - DNA Vaccination with Synthetic WT1 Constructs Result in the Induction of WT1-Specific T-Cell Responses That Can Inhibit Tumor Growth
  • InSphero, Inc. - Characterization and Application of 3D Multi-Donor Human Liver Microtissues for Predictive DILI Testing
  • InSphero, Inc. - Multi-Parametric 3D Tumor Microtissue-Based Phenotypic Compound Classification
  • IntelliCyt Corporation - High Throughput Flow Screening Assays to Profile Cell-Mediated Killing
  • Korea Institute of Toxicology - Inhibitory Mechanism of hERG Potassium Channel by an Antidepressant Nefazodone
  • Labcyte, Inc. - Serial Dilutions Can Generate Incorrect Data
  • Lead Discovery Center GmbH - Inhibitors of Mitochondrial Transcription (IMT) Specifically Affect Cancer Cell Proliferation
  • Life Chemicals, Inc. - Fragment Screening Libraries
  • Life Chemicals, Inc. - Screening Compound Libraries for HTS and Lead Discovery Projects
  • Massachusetts Institute of Technology - Polymer Backpacks for Cell-Based Therapies Across the Blood-Brain Barrier
  • National Health Research Institutes, Taiwan - Discovery of 1-(2,4-Dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a Novel Peripherally Restricted Cannabinoid-1 Receptor Antagonist with Significant Weight-Loss Efficacy in Diet-Induced Obese Mice
  • National Health Research Institutes, Taiwan - Zinc-Dipicolylamine Directed Pharmaceutical Delivery System (ZAPS) as an Innovative Cancer Drug Delivery Platform
  • National Laboratory for Scientific Computing, Brazil - DockThor Portal: A Free Docking Server for Accurate Prediction of Protein-Ligand Multiple Binding Modes
  • National Research Council Canada - Identification of Brain-Selective Receptors Using Next Generation Sequencing and Proteomics
  • National Yang-Ming University - Biological Characterizations of RGD-VEGF Fusion Protein as a Dual-Targeting Theranostic Agent
  • National Yang-Ming University - Local Oncothermia Treatment Enhances the Gold Nanoparticles Accumulation in a Sarcoma-Bearing Mouse Model
  • Netherlands Translational Research Center B.V. - Comparative Cancer Cell Line Profiling Differentiates the Mechanism of Action of Different PI3K/mTOR, Aurora Kinase and EZH2 Inhibitors
  • Newcastle University - Predicting Adverse Immune Responses to Biologics
  • Newcastle University - Rapid Detection of Immunogenicity and Adverse Reactions to New Compounds by In Vitro Assaying
  • Norwegian University of Science and Technology (NTNU) - Anti-Tumor Effect of an Oligosaccharide API in a Syngeneic Mouse Model of Breast Cancer
  • Novo Nordisk A/S - The GLP-1 Analog Liraglutide Access the CNS and Regulates Food Intake
  • Novogen Ltd. - Targeting Tropomyosin: Design, Synthesis and SAR of Some First-in-Class Cytoskeleton Targeting Substituted Indoles in Clinical Development for a Variety of Cancers
  • Oncodesign S.A. - From Syngeneic to Humanized Mouse Models: Addressing the Needs for Novel Immunotherapies (Efficacy Evaluation and Biomarker Discovery)
  • Optibrium Ltd. - Bridging the Dimensions: Seamless Integration of 3D Structure-Based Design and 2D Structure-Activity Relationships to Guide Medicinal Chemistry
  • Organovo, Inc. - Bioprinted Human Tissues for Toxicology and Disease Modeling
  • Pennsylvania State University - Evaluation of Multifunctional Nanovesicles in a Maliganant Peripheral Nerve Sheath Tumor Mouse Model
  • Pfizer Global Research and Development - EPSA: A Novel Supercritical Fluid Chromatography Technique Enabling the Design of Permeable Cyclic Peptides
  • Promega Corporation - Combining a Real-Time In Vitro Cell Viability Assay and RNA Extraction from the Same 3D Spheroids
  • Promega Corporation - Kinase Target Engagement and Drug Residence Time Using BRET
  • Promega Corporation - Measuring Intracellular Target Engagement via BRET at HDAC and BRD
  • Promega Corporation - Quantitative Cell-Based Bioassays for the Development of Antibody Therapeutics Targeting Individual or Combination Immune Checkpoint Receptors
  • ProQinase GmbH - Anti-PD-1, Anti-PD-L1 and Anti-CTLA-4 Checkpoint Inhibitor Treatment Leads to Different Responses in Syngeneic Tumor Models
  • Roche Innovation Center Zurich - Combining FAP-IL2v Immunocytokine with ADCC Competent Antibodies Against EGFR and TYRP1 and Immunomodulatory Antibody Against PD-L1
  • Sacred Heart Academy - RESTRICTIONS - Sequencing Analysis of the CpG Island in the VDR Gene of Bos taurus: The Regulation of Pluripotency
  • Sacred Heart Academy - RESTRICTIONS - Sequencing the Oct4 CpG Island in Bos taurus: An Epigenetic Analysis of Stem Cell Pluripotency
  • SCIVAX Life Sciences - Effect of Scaffold and Growth Factors on Anti-Cancer Drug Screening with Multicellular Spheroids: Mimicking In Vivo Response!
  • Southern Research Institute - Comparison of Two-Dimensional and Three-Dimensional Cell Systems in a Genetically Defined and Diverse 12 Cell Line Anticancer Compound Efficacy Screening Model
  • SQZ Biotech - CellSqueeze®: Vector-Free Intracellular Delivery of Membrane Impermeable Materials for Phenotypic Screening
  • STEMCELL Technologies, Inc. - Ultra-High Throughput Production of Spheroids with AggreWell
  • Sygnature Discovery - Heterogeneous Catalysis: A Key Tool in the Synthesis of sp3-Rich Scaffolds
  • Sygnature Discovery - Optimisation of a Series of Potent and Selective GR Antagonists
  • Taiho Pharmaceutical Co., Ltd. - Multi-Spheroid Imaging Analysis of Human iPS Cell-Derived Cardiomyocyte as a Assessment Model for the Acute Effects of Cardiotoxicity of Anti-Cancer Drugs
  • TARA Biosystems - Biowire II: Drug Testing Platform Using Matured Human Engineered Cardiac Tissue
  • Tetragenetics, Inc. - Antibodies Against Difficult to Express Membrane Protein Targets
  • Universidade NOVA de Lisboa - Liposome Delivery of a Sn(IV) Complex in Colorectal Cancer Model
  • University of Akron - High Throughput LC-MS/MS Investigation of LTP-Nanoparticles for the Treatment of Neurodegenerative Disease
  • University of Akron - Identification of the Metabolic Requirements for Myelin Formation Using Global Metabolomics
  • University of Antwerp - Chemokine Production by Cells of the BBB in Steady-State and Neuroinflammatory Conditions
  • University of Auckland - Interferon-γ Blocks Signalling Through PDGFRβ in Human Brain Pericytes
  • University of Auckland - Phagocytosis by Human Brain Pericytes: Implications for Alzheimer's Disease
  • University of California, San Francisco - Identification of an Oncogene-Specific Inhibitor of KRas G12D
  • University of Hull - MMP2-Dependent Shedding of the EMT-Suppressor/Promoter Receptor Endo180 from the Plasma Membrane in Breast Cancer is Inhibited by Bisphosphonate Treatment
  • University of Maryland, Baltimore - IL-1β-Mediated Inflammation Establishes Pre-Neoplastic Lesions in the Mouse Prostate
  • University of Minnesota - Brain Penetration and Binding of Ponatinib, a Multi-Kinase Inhibitor, in the Brain: Implications for the Treatment of Brain Tumors
  • University of North Carolina at Chapel Hill/Organovo, Inc. - Modeling Compound-Induced Fibrogenesis In Vitro Using Three-Dimensional Bioprinted Human Liver Tissues
  • University of Pennsylvania - Property-Based Design of Brain Penetrant Inflammation Inhibitors for Alzheimer's Disease
  • University of Southern Denmark - Epigenetic Markers and Histone Clipping Are Reproduced in Microgravity 3D Spheroids
  • University of Southern Denmark - Mimicking the Feeding-Fasting Cycle Using Microgravity 3D Spheroids
  • University of Tartu - Novel s-Triazine Derivates as HIV1 Non-Nucleoside Reverse Transcriptase Inhibitors
  • University of Wisconsin-Madison - Creation and Screening of a Lamprey Variable Lymphocyte Receptor Library Against Blood-Brain Barrier Endothelial Cell-Surface Antigens
  • University of Wisconsin-Madison - High Throughput and High Content Analysis of Gene Editing Using ArrayEdit
  • VIB and Ghent University - Importance of the Blood-Cerebrospinal Fluid Barrier in Alzheimer's Disease
  • Wiley - John Wiley & Sons - Identifying Synthetic Opportunities and Covering a Greater Chemical Space Using Computer-Aided Synthesis Design with ChemPlanner
  • Yeungnam University - BJ-1301, Alpha-Tocopherol Analog, Inhibits Angiogenesis and Lung Cancer Growth Through NADPH Oxidase



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