Cambridge Healthtech’s Inaugural

Applications of Digital Pathology

Preparing for a Fully Digital Workflow

August 20-21, 2019

 

The Inaugural Applications of Digital Pathology conference will review three main areas of implementation - in primary diagnosis in the U.S. and abroad, in telepathology and in combination with AI and machine learning tools. Digital pathology is vibrant with the influx of new technologies and the first FDA-approved platform, and the variety of hardware solutions and software tools is an indication that creativity and investment is transforming the pathology landscape. Progress in this field will greatly improve the practice of medicine.

Final Agenda

Recommended Short Course*

SC2: Discover How Machine Learning Can Complement Diagnoses through Medical Imagery

Helen Lam, Software Developer, Developer Advocate, IBM Watson

Nicholas Bourdakos, Software Developer, IBM Watson

In this hands-on session, learn how to train your own custom classifier using medical images to help augment your diagnoses. We will first cover the overview of available technologies for medical imagery in diagnosis, then will show examples by utilizing Watson Machine Learning and Tensorflow, an open source software library for high performance numerical computation to create a custom model.

SC7: Digital Pathology from A to Z for Beginners

Matthew G. Hanna, MD, Clinical Instructor, Breast and Informatics, Department of Pathology, Memorial Sloan Kettering Cancer Center

Digital pathology is a disruptive technology in the laboratory workflow. It has tremendous potential to change the way pathologists, researchers, and other personnel interact with pathology data. It is an exciting era of potentially practice-changing technology. Although digital pathology comes with significant promise, there are still numerous obstacles that stand in the way of becoming the next standard of care. Aside from clinical practice, digital pathology can be leveraged in the research and education arms of the medical community. This course will cover the nuts and bolts for all related topics in digital pathology for those who are just wondering what all the hype is about, to those who want a little more depth in their understanding of what digital pathology can and will do in the medical community.

*Separate registration required.

TUESDAY, AUGUST 20

7:30 am Registration and Morning Coffee

AI AND MACHINE LEARNING FOR DIGITAL PATHOLOGY

8:30 Chairperson’s Opening Remarks

Liron Pantanowitz, MD, Professor, Pathology & Biomedical Informatics, University of Pittsburgh Medical Center

8:40 KEYNOTE PRESENTATION: Legal Aspects of Artificial Intelligence

Allen_TimothyTimothy Craig Allen, MD, JD, FCAP, Professor and Chair, Department of Pathology, The University of Mississippi Medical Center

Artificial intelligence promises to increase healthcare efficiencies and accuracy and reduce cost. Its development, however, has been generally outside of any regulatory environment, and little legal scholarship about it currently exists. Successful artificial intelligence regulation will require an evolving regulatory strategy that abandons traditional normative boundaries, and instead will require shared governmental and stakeholder involvement. Medical malpractice liability theory will also require careful consideration and evolution as artificial intelligence evolves.

9:10 Searching Is Intelligence: AI Solutions for Medical Imaging

Tizhoosh_HamidHamid Tizhoosh, PhD, Professor, Computer Science; Director, Kimia Lab, Faculty Affiliate, Vector Institute, University of Waterloo

Image search has emerged as a very promising application of artificial intelligence. We will talk about different challenges of digital pathology and what AI algorithms could offer. Whereas most papers focus on classification and segmentation, this talk will attempt to shed light on challenges and opportunities of image search for retrieving useful information from large archives of histopathology images.

9:40 Augmented Human Intelligence and Transformation of Hematopathology Workflow

Salama_MohamedMohamed E. Salama, MD, Professor, Pathology and Laboratory Medicine, Mayo Clinic School of Medicine and Medical Director, Mayo Clinic Reference Laboratories

Hematopathologists are increasingly using digital imaging tools for a wide spectrum of practice settings. However, digital imaging associated with artificial intelligence applications for effective learning and diagnosis rendering are not yet routinely incorporated in practice. We will share our experience in utilizing digital tools and will demonstrate methods and applications of digital imaging along with augmented human intelligence to effectively improve the workflow in the practice of hematopathology. We will cover the essential elements as well as the pitfalls, advantages, challenges and opportunities in utilization of digital tools in practice.

10:10 Coffee Break in the Exhibit Hall with Poster Viewing

11:00 KEYNOTE PRESENTATION: Rules of Engagement of Academia with Industry: Lessons for Digital Pathology Collaborations

Becich_MichaelMichael J. Becich, MD, PhD, Associate Vice-Chancellor for Informatics in the Health Sciences; Chairman and Distinguished University Professor, Department of Biomedical Informatics (DBMI), University of Pittsburgh School of Medicine

Academic Industry Partnerships (AIPs) are key to successful “innovation cycles” within academic health systems (AHCs). This keynote describes the rules of engagement for faculty innovators and AHCs to evolve “best practices” for AIPs. Keys to successful efforts involve basic/translational researchers, technology transfer and university/health systems offices of research/compliance as well as industry relations officers. Guidelines for innovators establishing AIPs and appropriate management of conflict of interest policies will be discussed.

11:30 Digital Pathology for Primary Diagnosis: FDA Regulatory Review Process

Kalavar_ShyamShyam Kalavar, MPH, CT(ASCP), Senior Scientific Reviewer, Molecular Pathology and Cytology Branch, Division of Molecular Genetics and Pathology, Center for Devices and Radiological Health, Office of In Vitro Diagnostics and Radiological Health, U.S. Food and Drug Administration

FDA authorized the first digital pathology whole slide imaging system for primary diagnosis in 2017. This talk will provide a brief overview of the FDA regulatory review process for a marketing application for this type of a device and provide information about the types of studies and validation data needed to support the performance of the device. This talk will also briefly discuss regulatory perspective of issues such as interoperability and artificial intelligence as applicable to digital pathology.

12:00 pm Sponsored Presentation (Opportunity Available)

Cambridge-Consultants 12:30 Luncheon Presentation: Evolving AI to Enable the Next Generation of Digital Pathology

Corrgian_JoeJoe Corrigan, Head, Technology, Medical Technology, Cambridge Consultants

The development of AI tools and their integration into diagnostics systems present an opportunity to transform digital pathology. This transformation will not be restricted to whole slide imaging and evaluation steps of digital pathology. Instead, it will impact most of its aspects - from sample collection to diagnosis. In this talk, we will use our expertise from delivering AI enabled systems on behalf of our clients and we will explore the challenges of materialising the vision for next-generation digital pathology. Moreover, we will highlight the opportunities and underline the technological advantages which will catalyse this transformation.

1:00 Cookie & Refreshment Break in the Exhibit Hall with Poster Viewing

IMPLEMENTING TELEPATHOLOGY WORLDWIDE

1:30 Chairperson’s Remarks

Liron Pantanowitz, MD, Professor, Pathology & Biomedical Informatics, University of Pittsburgh Medical Center

1:35 Implementing Telepathology Worldwide: The Cleveland Clinic Experience

Bin Yang, MD, PhD, Professor of Pathology, Co-Director of ePathology (International); Director of International Business and Collaboration, Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic Lerner College of Medicine

Digital pathology provides an emerging role in telepathology consultations both domestically and internationally. Through innovational approaches, we have established a scanner-independent telepathology platform in our institution for eConsults to Chinese pathologists, patients and clinicians to offer guidance on diagnostic and prognostic findings to assist in therapeutic decision-making for international patients.

2:05 Challenges to Building International Digital Pathology Networks

Riben_MichaelMichael Riben, MD, Director of Informatics, MD Anderson Cancer Center

Collaborative digital pathology has been enhanced by commercial software solutions and has made tremendous progress in recent years. Many have even successfully developed connections between domestic and/or International partners. However, these implementations have been primarily point-to-point connections for the sharing of the images in isolation of pathology information or medical record information. Building a Digital pathology network for sharing both whole slide images and clinical information still faces many challenges, particularly if you wish to scale this to international partners. This talk will address the challenges that must be overcome for an international digital pathology network to be successful and highlight lessons learned along the way of planning such a network.

2:35 What You Need to Know About Performing Frozen Sections by Digital Scans

Pantanowitz_LironLiron Pantanowitz, MD, Professor, Pathology & Biomedical Informatics, University of Pittsburgh Medical Center

The use of telepathology for frozen sections (intraoperative consultations) has been increasing due to limited time and availability of pathologists, and the demand for increased access to pathology subspecialists in difficult cases. However, frozen sections can be difficult to handle remotely due to time constraints and artifacts. This talk will address the challenges, suitable IT solutions, practice tips and business aspects of performing remote frozen sections by telepathology.

3:05 Sponsored Presentation (Opportunity Available)

3:35 Refreshment Break in the Exhibit Hall with Poster Viewing

APPLICATIONS IN PRIMARY DIAGNOSIS

4:25 Chairperson’s Remarks

Anil Parwani, MD, PhD, MBA, Professor of Pathology and Biomedical Informatics, Vice Chair of Anatomic Pathology, Director of Pathology Informatics; Director, Digital Pathology Shared Resources, Wexner Medical Center - Department of Pathology, The Ohio State University

4:30 Implementing A Digital Pathology Workflow for Primary Diagnosis: A 2-Year Report Card

Parwani_AnilAnil Parwani, MD, PhD, MBA, Professor of Pathology and Biomedical Informatics, Vice Chair of Anatomic Pathology, Director of Pathology Informatics; Director, Digital Pathology Shared Resources, Wexner Medical Center - Department of Pathology, The Ohio State University

In recent years, whole slide imaging (WSI) has been increasingly used to digitize large numbers of slides automatically, rapidly and at high resolution. Some of the applications include education, quality assurance, clinical and image analysis. In our institution, we have validated and implemented WSI for multiple applications including primary diagnosis. This talk will address our experiences with implementing WSI for primary diagnosis and discuss technology, workflow, quality and financial opportunities.

5:00 Whitepapers of Digital Pathology from the Digital Pathology Association

Hartman_DouglasDouglas Joseph Hartman, MD, Associate Professor of Pathology and Director of Pathology Informatics, University of Pittsburgh Medical Center

The first approval of a digital pathology system has begun the transition of pathology from analog to digital. This process is being led by the Digital Pathology Association. To that end, the Digital Pathology Association and its members have been publishing whitepapers on the conversion of the discipline of pathology to a digital format. This talk will review the topics presented in these recent whitepapers.

5:30 Sponsored Presentation (Opportunity Available)


6:00 Wine & Cheese Pairing Welcome Reception in the Exhibit Hall with Poster Viewing

7:00 Close of Day

WEDNESDAY, AUGUST 21

7:15 am Registration


7:30 Problem Solving Breakout Discussions with Continental Breakfast

Impact of Digitization on the Practice Pathology

Moderator: Juan Antonio Retamero, MD, Staff Pathologist, Department of Anatomical Pathology, Hospital Campus de la Salud

  • Impact of digitization on the practice of the profession
  • The future of pathology: Digital and computational tools
  • Clearing roadblocks on the adoption of digital pathology

Image Analysis Challenges of Digital Pathology: What do Pathologists Need?

Moderator: Hamid Tizhoosh, PhD, Professor, Computer Science; Director, Kimia Lab, Faculty Affiliate, Vector Institute, University of Waterloo, Canada

  • Image segregation
  • Image classification
  • Image search
  • Tissue recognition
  • Survivability prediction

APPLICATIONS IN PRIMARY DIAGNOSIS (CONT.)

8:25 Chairperson’s Remarks

Douglas Joseph Hartman, MD, Associate Professor of Pathology and Director of Pathology Informatics, University of Pittsburgh Medical Center

8:30 Complete Digital Pathology for Routine Histopathology Diagnosis: Three Years’ Experience at Granada University Hospitals, Spain

Retamero_JuanJuan Antonio Retamero, MD, Staff Pathologist, Department of Anatomical Pathology, Hospital Campus de la Salud

Granada University Hospitals comprises two teaching and two district general hospitals integrated in the public health system in southern Spain. We report on the transition to full digital pathology for primary histopathology diagnosis and our experiences since its implementation in September 2016.

9:00 Application of AI Tools in Routine Digital Workflow: The Catania Experience

Fraggetta_FilippoFilippo Fraggetta, MD, Head of the Pathology Department, Cannizzaro Hospital

At Cannizzaro Hospital in Catania, Italy, we use e-slides for primary diagnosis since 2017. Using a Laboratory Information System centric approach to the workflow, we integrated Artificial Intelligence tools in our routine digital workflow to facilitate automated tumor detection (in prostate and breast cancer) and detection microorganisms (Helicobacter pylori). We discuss results of this new approach as well as difficulties and solutions to the implementations of these tools.

9:30 Building the Foundation of Digital Pathology in the Diagnostic Setting: Guiding Principles and Practical Issues

Cheng_CheeLeongChee Leong Cheng, MBBS, FRCPath, FRCPASingapore, Senior Consultant, Anatomical Pathology; Director, Computational and Digital Pathology, Singhealth Pathology ACP; Department of Anatomical Pathology, Singapore General Hospital

Digital pathology with application of whole slide imaging (WSI) in the diagnostic setting demands the integration of WSI process into the diagnostic workflow. The key considerations include integration with laboratory information system, end-to-end accountability of specimen assets and derivatives, thorough view of electronic information flow closely correlated with the workflow, sound validation planning and execution, and continuous monitoring and sustainability by building a “digital pathology service” in the laboratory.

10:00 Sponsored Presentation (Opportunity Available)

10:30 Coffee Break in the Exhibit Hall with Poster Viewing


11:30 Plenary Keynote Session

11:30 Chairperson’s Remarks

Charles Mathews, Principal, ClearView Healthcare Partners

 

 

 

 

 

11:40 Plenary Keynote Presentation: FDA Updates: Now and Looking to the Future

Tim Stenzel, MD, PhD, Director, Office of In Vitro Diagnostics and Radiological Health, Center for Devices and Radiological Health, U.S. Food and Drug Administration

Introduction and background of the new Office Director of OIR and updates on precision medicine and other initiatives at the FDA.

12:10-1:05 pm Plenary Keynote Discussion: Proposals and Solutions for Diagnostic Reform Including Oversight of Laboratory Developed Tests (LDTs)

Moderator:
Cynthia A. Bens, Senior Vice President, Public Policy, Personalized Medicine Coalition

 

 

 

 

  • How are stakeholders influencing congressional activity on the Verifying Accurate Leading-edge IVCT Development (VALID) Act?
  • How will the VALID Act change the current oversight landscape for diagnostics, including LDTs?
  • How are policymakers addressing the role of CMS and CLIA in the VALID Act?
  • How will increased regulatory and oversight activities at the FDA affect the diagnostics industry?
  • What impact will changes in diagnostics regulation and oversight have on patient care?

Panelists:

Julie Khani, MPA, President, American Clinical Laboratory Association (ACLA)

 

 

 

 

 

Donald E. Horton, Jr., Senior Vice President, Global Government Relations & Public Policy, Laboratory Corporation of America Holdings

 

 

 

 

 

Susan Van Meter, Executive Director, AdvaMedDx

 

 

 

 

 

Tara Burke, PhD, Senior Director, Public Policy & Advocacy, Association for Molecular Pathology (AMP)

 

 

 

 

 

1:05 pm Luncheon Presentation (Sponsorship Opportunity Available) or Enjoy Lunch on Your Own

1:35 End of Applications of Digital Pathology


Recommended Short Course*

SC13: Data-Driven Process Development in the Clinical Laboratory

Young_RobertRobert Young, CGMBS, MS Bioinformatics, Owner, Principal Consultant, Lab Insights, LLC

The modern clinical laboratory utilizes complex, data-rich computer systems. In this course, you will learn how to leverage your laboratory information systems to build data-driven processes, create data-driven process improvements, and make data-driven business decisions.

*Separate registration required.

* The program is subject to change without notice, due to unforeseen reason.