Cambridge Healthtech Institute’s 5th Annual

Advances in Purification & Recovery

Intensifying and Optimizing Downstream Process

August 14-15, 2019


New and emerging molecules coming down the pipeline brings a new set of challenges to the downstream team. Downstream scientists are thus increasingly looking to process intensification and optimization methods, automation, mechanistic modeling and high throughput processes to meet the challenges of higher upstream titers and complex molecules while improving products and reducing cost.

CHI’s 5th Annual Advances in Purification & Recovery invites scientists to share their pursuit of new materials such as custom affinity resins and novel membranes, or new technologies such as automation, predictive modeling and intensification methods, to develop next-generation processes and products.

Preliminary Agenda

PURIFICATION OF NOVEL MODALITIES AND ALTERNATIVE EXPRESSION SYSTEMS

KEYNOTE PRESENTATION: Challenges and Innovations in Downstream Processing of Gene Therapy Products

Roman Necina, PhD, Chief Strategist and Head, Special Projects, Pharmaceutical Sciences, Takeda Austria

Development of a Robust Purification and Separation Strategy for a Novel ADC Platform

Engin Ayturk, PhD, Director, CMC Process Engineering, Mersana

NEW MATERIALS & NOVEL TECHNOLOGIES

Perforated Nanomembranes for Separation of Proteins

Alois Jungbauer, PhD, Professor, Biotechnology, University of Natural Resources and Life Sciences, Vienna and Austrian Centre of Industrial Biotechnology

Revolutionising Chromatography: 3D Printed Monoliths for Protein Chromatography

Ursula Simon, Senior PhD Student, School of Engineering, University of Edinburgh

EVOLUTION OF EXISTING STRATEGIES AND SYSTEMS TO NEXT-GENERATION DOWNSTREAM PROCESSING

Functionalized Protein Nanoparticle Crosslinking for Enhanced Affinity Precipitation of Monoclonal Antibodies

Wilfred Chen, PhD, Gore Professor, Chemical and Biomolecular Engineering, University of Delaware

Enhancing Virus Filter Throughput for Hydrophobic Proteins

Lu Wang, PhD, Senior Scientist, Teva Pharmaceuticals

Learning Opportunities During Commercial Manufacturing

Ronald Bates, PhD, Director, MS&T, Bristol-Myers Squibb

PROCESS INTENSIFICATION AND OPTIMIZATION: MINIMIZING, CONCENTRATING, SIMPLIFYING

The Search for Process Intensification and Simplification: Alternative Approaches versus Current Platform Processes for Monoclonal Antibodies

Robert Gronke, PhD, Senior Principal Scientist, ASO Process Development & Manufacturing, Biogen, Inc.

Leveraging Displacement to Enhance Ion-Exchange Chromatography of Product-Related Variants

Abraham Lenhoff, PhD, University of Delaware


* The program is subject to change without notice, due to unforeseen reason.