Cambridge Healthtech Institute’s 4th Annual

Oncolytic Virus Immunotherapy

Realizing the Exciting Potential of Oncolytic Virotherapy

August 6-7, 2019



Oncolytic virotherapy (OV) represents an exciting new area of cancer treatment by exploiting a virus’s ability to selectively replicate and kill tumor tissue while stimulating a patient-specific immune response against cancer. Interest in the field is at an all-time high following significant scientific breakthroughs in mechanisms of action, efficacy, combination therapies, delivery, and investment from big pharma players such as Pfizer, Amgen, Merck, Johnson and Johnson.

CHI’s Oncolytic Virus Immunotherapy conference brings together leading industry and academic leaders to discuss the critical steps needed to accelerate oncolytic virus immunotherapy, from delivery to combination therapy strategies; virus engineering to manufacturing and commercialization.

Final Agenda

TUESDAY, AUGUST 6

12:00 pm Registration

LATEST UPDATES AND FUTURE DIRECTIONS IN ONCOLYTIC VIROTHERAPY

1:25 Chairperson’s Opening Remarks

Paola Grandi, PhD, CSO, Cold Genesys


1:30 KEYNOTE PRESENTATION: Treatment of Glioma Using Tumor-Targeted Oncolytic HSV Armed with Immunomodulatory Genes

Joseph C. Glorioso, PhD, Professor, Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine

Glioblastoma multiforme (GBM) is a deadly form of brain cancer that is resistant to the standard of care. A robust, tumor targeted oncolytic herpes simplex virus (oHSV) will be described that has been armed with immunomodulatory genes that partially overcome the MDSC-enriched immunosuppressive tumor microenvironment and promote the development of anti-tumor immunity.

2:00 KEYNOTE PRESENTATION: Directed Evolution & Rational Design Approaches to the Design & Engineering of Optimized Oncolytic Virus Therapeutics for IV Delivery (IGV-101)

David Kirn, MD, Co-Founder & Executive Chairman, IGNITE Immunotherapy

Hurdles to efficacy and safety of oncolytic viruses include IV delivery, anti-viral immunity, transgene carrying capacity, intratumoral spread and tumor resistance mechanisms. Opportunities include direct oncolytic activity plus induction of anti-cancer immunity. We will present data on the directed evolution and rational design platform approaches that IGNITE Immunotherapy has applied in the design and engineering of next-generation oncolytic viruses. Data from a lead IND candidate will be presented.

2:30 Creating an Immunotherapeutic Battleship to Overcome Tumor Heterogeneity

John Bell, PhD, Senior Scientist, Center for Innovative Cancer Research, Ottawa Hospital Research Institute

3:00 An Integrated Approach to Managing Immunogenicity Risk and Optimum Protein Design

Emilee Knowlton, PhD, Immunology Sales Specialist, Sales, ProImmune, Inc.

Integrated platforms can be used to mitigate immunogenicity risk and characterize immune responses during the drug design and development stages. ProImmune offers mutational activity mapping for optimal protein design, DC-T/T cell proliferation assays for biologic lead selection/optimization, a Mass Spectrometry assay for characterization of antigen presentation; HLA-peptide binding assays to characterize individual epitopes and undiluted whole blood cytokine storm assays.

3:30 Refreshment Break in the Exhibit Hall with Poster Viewing


4:15 PLENARY KEYNOTE SESSION

PANEL DISCUSSION: Next-Generation Immunotherapies

CHI’s Immuno-Oncology Summit brings you the latest advances in immunotherapy every year. This panel of industry thought leaders will discuss the technology advances and implementation strategies for next-generation immunotherapies, including emerging immunotherapy combinations, bispecific antibodies, oncolytic virotherapy, adoptive cell therapy, personalized vaccines and neoantigen targeted therapies, small molecules and ADCs, cytokines, and innate immunity targeted therapies.

Moderator

Pamela Carroll, PhD

Senior Vice President, Immuno-Oncology, Genocea Biosciences

 

 

 

 

Panelists

Rakesh Dixit

PhD, DABT, Vice President, R&D; Global Head, Biologics Safety Assessment, MedImmune

 

 

 

 

Tara Arvedson, PhD

Director, Oncology Research, Amgen

 

 

 

 

Stephen Doberstein, PhD

Senior Vice President, R&D and Chief Research and Development Officer, Nektar Therapeutics

 

 

 

 

Raymond Tesi, MD

CEO/CMO, INmune Bio

 

 

 

 

David Kirn, MD

Co-Founder & Executive Chairman, IGNITE Immunotherapy

 

 

 

 

5:30 Welcome Reception in the Exhibit Hall with Poster Viewing

WEDNESDAY, AUGUST 7

7:30 am Registration Open and Morning Coffee

COMBINATIONAL STRATEGIES TO ENHANCE ACTIVITY

8:25 Chairperson’s Remarks

Samuel D. Rabkin, PhD, Professor, Neurosurgery, Massachusetts General Hospital and Harvard Medical School

8:30 Advances in Oncolytic Virus Development

Howard Kaufman, PhD, CMO, Replimune

Replimune has developed an oncolytic immunotherapy platform augmenting the oncolytic capability of HSV-1 and enhancing anti-tumor immunity. Replimune’s viruses are armed with multiple therapeutic genes, including a fusogenic glycoprotein and GM-CSF (RP1), currently in Phase 1/2 trials alone and in combination with nivolumab. Viruses expressing anti-CTLA-4 (RP2) and co-stimulatory ligands (RP3) have been tested in preclinical models and are expected to enter clinical development in 2019 and 2020, respectively.

9:00 Next Generation OV and New Combinational Approaches for Treatment of Solid Tumors

Paola Grandi, PhD, CSO, Cold Genesys

In the last few years, oncolytic vectors have become one of the most promising immuno-therapy agents for the treatment of cancer. Leaders from academia and industry have made advances in vector engineering, explored advantages and limitations of preclinical models, discussed updates from combination trials, as well as shared challenges and potential strategies of systemic delivery. In this talk, I will present an overview of the Phase II clinical trial with CG0070 for the treatment of BCG-unresponsive bladder cancer.

9:30 Combinatorial Treatment with Oncolytic Adenoimmunotherapy and CAR T-Cell Therapy for Solid Tumor Treatment

Masataka Suzuki, PhD, Assistant Professor, Center for Cell & Gene Therapy, Department of Medicine, Baylor College of Medicine

In solid tumors, CAR T-cells must overcome the challenges of the immunosuppressive tumor microenvironment. We hypothesized that pre-treating tumors with our binary oncolytic adenovirus (CAd) that produces local oncolysis and expresses immunostimulatory molecules would enhance the antitumor activity of HER2-specific CAR T-cells, which alone are insufficient to cure solid tumors. Our results suggest that local treatment of our “all-in-one” vector can systemically enhance adoptive T cell responses to cancer cells.

10:00 Sponsored Presentation (Opportunity Available)

10:30 Coffee Break in the Exhibit Hall with Poster Viewing

11:30 MEK Inhibition Enhances Oncolytic Virus Immunotherapy through Increased Tumor Cell Killing and T Cell Activation

Howard Kaufman, PhD, CMO, Replimune

Talimogene laherparepvec (T-VEC) is a herpes simplex type 1 oncolytic virus, and trametinib is a MEK inhibitor approved for treatment of melanoma. We observed that the combination of T-VEC and trametinib resulted in enhanced melanoma cell death in vitro. Further, combination treatment resulted in delayed tumor growth and improved survival in mouse models. Tumor regression was dependent on activated CD8+ T cells and Batf3+ dendritic cells. These data support clinical development of combination oncolytic viruses, MEK inhibitors, and checkpoint blockade in patients with melanoma.

12:00 pm T-SIGn Virus Approach to Cancer Gene Therapy – Driving the Tumor Cells to Express Combinations of Biological Therapeutics within the Tumor Microenvironment

Brian Champion, PhD, CSO, Psioxus Therapeutics

Enadenotucirev is an Ad11p/Ad3 chimeric adenovirus with potent and selective anti-tumor activity, with a blood stability profile that enables systemic dosing. It has been administered intravenously to over 100 cancer patients. Tumor-Specific Immuno-Gene Therapy (T-SIGn) gene therapy vectors are modified viruses that retain all the functional properties of enadenotucirev, while also mediating the expression of therapeutic transgenes. Each T-SIGn virus is designed to target a different immunological phenotype of tumor.

12:30 Luncheon Presentation (Sponsorship Opportunity Available) or Enjoy Lunch on Your Own

1:00 Session Break

IMPROVING OV POTENCY AND EFFICACY

1:55 Chairperson’s Remarks

Matthew Mulvey, PhD, CEO, BeneVir Biopharm, Inc.

2:00 Enhancing Oncolytic HSV Therapy

Balveen Kaur, PhD, Professor, Vice-Chair Research, John P. and Kathrine G. McGovern Endowed Chair, Smith Department of Neurosurgery, University of Texas

Here we will report the ability of a PTENα expressing oncolytic herpesvirus, to eradicate cancer and its ability to abrogate PD-L1 expression in infected tumor cells, thus priming an adaptive immune response and overcoming tumor immune escape. A single dose of HSV-P10 resulted in long term survivors that rejected subsequent tumor challenge. Our findings implicate HSV-P10 as an oncolytic and immune stimulating therapeutic for anticancer therapy.

2:30 Novel Micro-RNA Attenuated Oncolytic HSV Virus with Combinatorial Immune Payloads for the Treatment of Metastatic Cancer

Christophe Queva, PhD, CSO, Oncorus

Oncorus is developing the next generation HSV-based oncolytic virus with enhanced potency for tumor cell killing and recruitment of the immune system. Our innovative miR-attenuation strategy enables robust viral replication in tumor cells, while preventing replication in healthy tissue. Oncorus’ oHSV are armed with multiple immunomodulatory payloads to synergistically increase recruitment and effector function of immune cells, thus harnessing the full potential of OVs to evoke an abscopal immune response.

3:00 Systemic OV Therapy Using Voyager-V1

Stephen J. Russell, MD, PhD, CEO, Vyriad, Inc.

Voyager-V1 is an oncolytic rhabdovirus designed for systemic cancer therapy and engineered to target immunosuppressive tumors where it mediates inflammatory tumor cell killing. Proinflammatory and anticancer activities of a single intravenous infusion of Voyager-V1 have already been confirmed in ongoing phase 1 clinical trials. Also, noninvasive tracking of the infection in patients treated with virus alone, or with virus-drug combination therapies, is being used to guide its further clinical development.

3:30 Refreshment Break in the Exhibit Hall with Poster Viewing

4:15 Retroviral Replicating Vectors for Conditionally Oncolytic Immunotherapy: Clinical Update and Translational Pipeline

Noriyuki Kasahara, MD, PhD, Alvera L. Kan Endowed Chair, Professor in Residence, Departments of Neurological Surgery and Radiation Oncology, University of California

4:45 PeptiCRAd - A Novel Personalized Oncolytic Vaccine Platform

Sari Pesonen, PhD, Vice President, Scientific and Clinical Development, Valo Therapeutics

PeptiCRAd™ is a patented oncolytic vaccine platform combining strong immune adjuvant (live oncolytic virus) and tumor epitopes to enable a robust anti-tumor immune response against tumor antigens. Technology allows rapid adaptation to changing tumor epitopes and multiple tumor targets without the need to manipulate the viral backbone. Induction of tumor-specific CD8+ T-cell response linked to tumor growth control was demonstrated in humanized mouse models. Phase1 trial is planned for Q4/2019.

5:15 Oncolytic Adenoviruses Expressing Hyaluronidase: Evidence of Clinical Activity in Different Tumor Indications

Manel Cascallo, PhD, CEO, VCN Bioscience

VCN Biosciences has developed different oncolytic adenoviruses expressing hyaluronidase: VCN-01 is a first-in-class virus clinically tested in different clinical trials in pancreatic cancer, retinoblastoma and head & neck adenocarcinoma. To date it has demonstrated a good safety profile and its ability to modify tumor matrix favoring therapeutics accessibility and immune infiltration. VCN-11 is a next generation hyaluronidase–expressing adenovirus able to evade anti-adenovirus neutralizing antibodies showing promising preclinical data.

5:45 pm Close of Oncolytic Virus Immunotherapy

5:45 Dinner Short Course Registration

6:30 Dinner Short Course: Development of Bioassays for Checkpoint Immunotherapy and Other Immuno-Oncology Leads*

*Separate registration required.

* The program is subject to change without notice, due to unforeseen reason.

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Update History
2019/06/20
Sponsor updated
2019/05/17
Agenda,Sponsor updated
2019/04/10
Agenda updated
2019/04/09
Agenda,Sponsor updated
2019/03/28
Sponsor updated