RNA molecules are crucial for delivering cellular information and genetic regulation, but until recently, the drug discovery world has emphasized protein drug targets. Our lack of knowledge in RNA biology prevented us from exploring possibilities of RNA drug targets, but with recent advances in technologies such as sequencing, new therapeutic strategies are being explored. Join us at the Inaugural RNA as a Drug Target conference, part of Discovery on Target, as we discuss RNA as a novel target site for therapeutics.
Small Molecules to Target RNA
FEATURED PRESENTATION: Non-Coding RNA as a Small Molecule Drug Target
Elliott Nickbarg, PhD, Principal Scientist, Pharmacology Department, Merck & Co, Inc.
Directly Targeting RNA with Small Molecules
Meizhong Jin, PhD, Senior Director, Chemistry, Arrakis Therapeutics
Targeting Structurally and Functionally Diverse RNAs with Drug-Like Small Molecules
John S. Schneekloth Jr. (Jay), PhD, Principal Investigator, Chemical Biology Laboratory; Head, Chemical Genetics Section, Center for Cancer Research, National Cancer Institute, NIH
RNA Splicing Target Identification
Tom Chappie, Associate Research Fellow, Pfizer
Identification of Development Candidate eFT226, a First in Class Inhibitor of eIF4A RNA Helicase
Justin Ernst, PhD, Director of Medicinal Chemistry, Effector Therapeutics
Modulating the Epitranscriptomic RNA Modifications for Cancer Therapy
Pawel Sledz, PhD, Senior Scientist, Department of Biochemistry, University of Zurich
Finding the Druggable Structures
Enabling Modulation of RNA Biology in Human Disease with Small Molecules
Razvan Nutiu, PhD, Investigator, Chemical Biology & Therapeutics, Novartis
Structure-Based Discovery of New Functions in Large RNAs
Kevin Weeks, PhD, Kenan Distinguished Professor of Chemistry, University of North Carolina
Oligonucleotides to Target RNA
FANA ASO Therapy to Silence Foxp3, Impair Treg Function and Promote Anti-Tumor Immunity
Wayne Hancock, PhD, Professor of Pathology and Laboratory Medicine, University of Pennsylvania, Chief of the Division of Transplant Immunology, Children’s Hospital of Philadelphia (CHOP)
* The program is subject to change without notice, due to unforeseen reason.