Cambridge Healthtech Institute Training Seminars offer real-life case studies, problems encountered and solutions applied, along with extensive coverage of the academic theory and background. Each training seminar offers a mix of formal lecture and interactive discussions and activities to maximize the learning experience. These training seminars are led by experienced instructors who will focus on content applicable to your current research and provide important guidance for those new to their fields.

Monday, 18 November and Tuesday, 19 November
Day 1: 13:30 – 18:20 | Day 2: 8:30 – 18:30

TS6A: Deep Sequencing and Single Cell Analysis
Brandon DeKosky, PhD, Assistant Professor, Department of Chemical Engineering, Department of Pharmaceutical Chemistry, Kansas Vaccine Institute, The University of Kansas

Wednesday, 20 November and Thursday, 21 November
Day 1: 8:30 – 17:45 | Day 2: 8:30 – 12:45

TS6B: Genome Editing with CRISPR: Toward Novel Research, Translational and Clinical Applications
This rigorous day and a half program compiled for specialists interested in applying genome editing technologies for both basic and translational research will comprehensively review the state-of-art information on gene editing strategies and applications in various areas, such as disease modelling, drug discovery and development. Beginning from introductory level basic technology aspects, key molecular features, strengths and shortcomings of CRISPR/Cas9 systems, the instructor will advance towards sharing in-depth knowledge related to virtually all facets of present day genome editing applications, such as constructing of cell culture-based experimental platforms, engineering disease models for in vivo research supporting preclinical drug development workflows, rational design and functional screening of sgRNA libraries, application of CRISPR/Cas9 technology for diagnostic and therapeutic purposes and many others.

Serguei V. Kozlov, PhD, MBA, PMP, Principal Scientist/PM, Team Leader PTO, Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research (NCI)

TS7B: Rational Approaches to Biologics Formulation and Delivery
This course is intended to give participants an understanding of the basic principles of biologics formulation development, with an emphasis on maintaining long term product stability. Participants should expect to come away with a better understanding of biochemical and biophysical properties of proteins and peptides, and how excipients and other strategies can be used to mitigate degradation. Formulation development discussions will cover both liquid and lyophilized dosage forms. The focus of the session will be on maximizing efficiency during formulation development, with an eye on regulatory compliance throughout the product development lifecycle. As such, following the introduction to formulation development, we will cover more complex formulation development topics including strategies for the formulation of low solubility APIs, advice for the selection of container/closure systems and drug delivery devices, as well as the studies that must be performed to demonstrate the compatibility of those materials with the product.

Christina Vessely, PhD, Senior Consultant, CMC, Analytical and Formulation Development, Biologics Consulting

* The program is subject to change without notice, due to unforeseen reason.

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