As more and more biological drugs are developed, an increasing demand falls on achieving pure protein, either for research or for therapeutic development. Achieving pure protein quicker and cheaper is essential, while also ensuring protein quality. Researchers must streamline the steps required to achieve purity, but protein’s intrinsic nature can cause headaches and frustrations. When faced with greater protein challenges, such as membrane proteins, expanding the purification toolbox becomes extremely helpful.
In addition, new technologies are continually emerging that offer support, and traditional techniques, such as chromatography and Protein A, are also being innovated. The “Protein Purification Technologies” conference explores current strategies that are proving successful, and looks at new ways to streamline techniques in the continual quest for purity.
ADVANCES IN CHROMATOGRAPHY
KEYNOTE PRESENTATION: New Chromatographic Processes for the Purification of Proteins
Massimo Morbidelli, PhD, Professor, Chimica, Materiali e Ingegneria Chimica, Politecnico di Milano
Advanced Chromatography-Free Protein Purification Strategies Enabling High-Resolution Structure Determination of Large, Labile Multi-Subunit Biological Assemblies and Drug Discovery
Ashwin Chari, PhD, Project Group Leader, Structural Dynamics, Max Planck Institute for Biophysical Chemistry
A Development and Manufacturing Platform for Non-Platform Proteins
Matthias Berkemeyer, PhD, Associate Director, Downstream Development, NBE and Biosimilars, Biopharma Process Science Austria, Boehringer Ingelheim RCV GmbH & Co KG
Improved Downstream Processing of Recombinant Proteins Using Aqueous Two-Phase Systems Composed of Ionic Liquids
Augusto Pedro, PhD, Post-Doctoral Fellow, Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro
Overcoming Limitations of Conventional Tag Systems – Strep-Tactin®XT Applications
Dennis Karthaus, MSc, Group Leader Cell Culture Sciences, IBA Lifesciences
INNOVATING ANTIBODY PURIFICATION
Overcoming Some Challenges in the Purification of Bispecific Antibodies
Ana Correia, PhD, Scientist, Biologics Optimization, Amgen, Inc.
Novel Protein A Small and Large-Scale Purification Platforms for Bispecific Antibodies
Afshin Mahmoudi, MS, Biotherapeutics, Signal Pharmaceuticals, LLC (a wholly owned subsidiary of Celgene Corp.)
PURIFYING MEMBRANE PROTEINS
The Gram-Negative Bacterial Cell Surface: How to Study its Protein Components and How to Remove Endotoxin
Dirk Linke, PhD, Professor, Molecular Microbiology, Biosciences, University of Oslo
A Tricky Endeavour: Production of Membrane-Bound P450s
Oliver Spadiut, PhD, Associate Professor, Chemical, Environmental and Bioscience Engineering, Integrated Bioprocess Development, Vienna University of Technology (TU Wien)
Sane in the Membrane - Salipro One-Step Reconstitution of Membrane Proteins
Jens Frauenfeld, PhD, CEO, Salipro Biotech AB
BREAKTHROUGH SUPPORTIVE TECHNOLOGY
A Microfluidic Platform for Antibodies Manufacturing Optimization
Raquel Aires-Barros, PhD, Professor, Bioengineering, Instituto Superior Técnico
Protein Separation by Magnetic Particles in the Technical Scale
Sonja Berensmeier, PhD, Professor, Mechanical Engineering, Bioseparation Engineering, Technical University of Munich
* The program is subject to change without notice, due to unforeseen reason.