As more and more biological drugs are developed, an increasing demand falls on achieving pure protein, either for research or for therapeutic development. Achieving pure protein quicker and cheaper is essential, while also ensuring protein quality. Researchers must streamline the steps required to achieve purity, but protein’s intrinsic nature can cause headaches and frustrations. When faced with greater protein challenges, such as membrane proteins, expanding the purification toolbox becomes extremely helpful.

In addition, new technologies are continually emerging that offer support, and traditional techniques, such as chromatography and Protein A, are also being innovated. The “Protein Purification Technologies” conference explores current strategies that are proving successful, and looks at new ways to streamline techniques in the continual quest for purity.

Preliminary Agenda

ADVANCES IN CHROMATOGRAPHY

KEYNOTE PRESENTATION: New Chromatographic Processes for the Purification of Proteins

Massimo Morbidelli, PhD, Professor, Chimica, Materiali e Ingegneria Chimica, Politecnico di Milano

Advanced Chromatography-Free Protein Purification Strategies Enabling High-Resolution Structure Determination of Large, Labile Multi-Subunit Biological Assemblies and Drug Discovery

Ashwin Chari, PhD, Project Group Leader, Structural Dynamics, Max Planck Institute for Biophysical Chemistry

INNOVATIVE STRATEGIES

A Development and Manufacturing Platform for Non-Platform Proteins

Matthias Berkemeyer, PhD, Associate Director, Downstream Development, NBE and Biosimilars, Biopharma Process Science Austria, Boehringer Ingelheim RCV GmbH & Co KG

Improved Downstream Processing of Recombinant Proteins Using Aqueous Two-Phase Systems Composed of Ionic Liquids

Augusto Pedro, PhD, Post-Doctoral Fellow, Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro

Overcoming Limitations of Conventional Tag Systems – Strep-Tactin®XT Applications 

Dennis Karthaus, MSc, Group Leader Cell Culture Sciences, IBA Lifesciences

INNOVATING ANTIBODY PURIFICATION

Overcoming Some Challenges in the Purification of Bispecific Antibodies

Ana Correia, PhD, Scientist, Biologics Optimization, Amgen, Inc.

Novel Protein A Small and Large-Scale Purification Platforms for Bispecific Antibodies

Afshin Mahmoudi, MS, Biotherapeutics, Signal Pharmaceuticals, LLC (a wholly owned subsidiary of Celgene Corp.)

PURIFYING MEMBRANE PROTEINS

The Gram-Negative Bacterial Cell Surface: How to Study its Protein Components and How to Remove Endotoxin

Dirk Linke, PhD, Professor, Molecular Microbiology, Biosciences, University of Oslo

A Tricky Endeavour: Production of Membrane-Bound P450s

Oliver Spadiut, PhD, Associate Professor, Chemical, Environmental and Bioscience Engineering, Integrated Bioprocess Development, Vienna University of Technology (TU Wien)

Sane in the Membrane - Salipro One-Step Reconstitution of Membrane Proteins

Jens Frauenfeld, PhD, CEO, Salipro Biotech AB

BREAKTHROUGH SUPPORTIVE TECHNOLOGY

A Microfluidic Platform for Antibodies Manufacturing Optimization

Raquel Aires-Barros, PhD, Professor, Bioengineering, Instituto Superior Técnico

Protein Separation by Magnetic Particles in the Technical Scale

Sonja Berensmeier, PhD, Professor, Mechanical Engineering, Bioseparation Engineering, Technical University of Munich



* The program is subject to change without notice, due to unforeseen reason.



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