Cambridge Healthtech Institute’s 2nd Annual

Deep Sequencing and Single Cell Analysis for Antibody Discovery

January 23-24, 2020

Part of the Protein Engineering & Development pipeline


The rapid adoption of deep sequencing and single B cell analysis has given discovery scientists an extraordinary view into human and animal immune repertoires that is now informing all aspects of biopharmaceutical R&D. This dynamic field is bringing together the disciplines of immunology, structural and computational biology, informatics and microfluidics to offer previously unimaginable perspectives that will drive discovery of the next generation of biologic drugs. PepTalk’s 2nd Annual Deep Sequencing and Single Cell Analysis for Antibody Discovery conference explores new science and technology in this field and how these advanced capabilities are being implemented and integrated with platforms, workflows and traditional discovery methods.


Coverage will include, but is not limited to:

  • Advanced applications (long-read sequencing, measuring metabolism, high-throughput single plasma cell sequencing, keeping cells alive, assaying extracellular vesicles at the single-cell level)
  • Automation to support complex functional screens
  • Build v. buy – developing internal capabilities versus external collaborations and platforms
  • Development and implementation of on chip assays
  • Direct selection from repertoires
  • Display-based human cell platforms integrated with droplet microfluidics
  • Functional characterization of NGS data
  • Have we hit a wall? How deeply can/should we mine repertoires?
  • Methods to evaluate the dynamics of multiple single cells
  • Reconciling differences in cell lines and bulk assays
  • Screening for bispecifics/multispecifics without having to reformat leads
  • Single-cell assays for difficult targets (membranes, intracellular, RNA)


* The program is subject to change without notice, due to unforeseen reason.

2020 Conferences & Training Seminars