Cambridge Healthtech Institute’s 12th Annual

Engineering Genes, Vectors, Constructs, and Clones

Exploring Tools and Developing Strategies to Expand the Protein Expression Toolbox

January 20-21, 2020

Part of the Biotherapeutic Expression & Production pipeline

The demand for high-quality biotherapeutic proteins has never been greater. Many variables still must be considered during the cell-line development process, including verification and sequence analysis of the gene or protein of interest, codon optimization, vector construction, and clone/host selection – a time-consuming and expensive process. Additionally, protein expression scientists are now exploring new engineering tools, such as synthetic biology and systems engineering. Ultimately, these tools must be weighed against traditional expression and production strategies to achieve the desired quantity and quality. Cambridge Healthtech Institute’s 12th Annual Engineering Genes, Vectors, Constructs, and Clones conference continues the tradition of applying effective engineering strategies for protein expression and production research leading to functional biotherapeutic products. Learn from seasoned, savvy researchers as they share their real-world experiences, applications, and results.

Preliminary Agenda


Transposon-Encoded CRISPR–Cas Systems Direct RNA-Guided DNA Integration

Samuel H. Sternberg, PhD, Assistant Professor, Department of Biochemistry and Molecular Biophysics, Columbia University

Defending Engineered Bacteria Against Evolutionary Failure

Jeffrey Barrick, PhD, Associate Professor, Molecular Biosciences, The University of Texas at Austin


Engineering a Cell Factory

Bjørn Voldborg, MSc, Director, CHO Cell Line Development, The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark


Democratizing Cell-Free Protein Synthesis: Improving Access for Broad Bioengineering Applications

Javin Oza, PhD, Assistant Professor, Synthetic Biology, California Polytechnic State University


FEATURED PRESENTATION: Codon and Codon-Pair Usage Tables (CoCoPUTs): Facilitating Genetic Variation Analyses and Recombinant Gene Design

Chava Kimchi-Sarfaty, PhD, OTAT Deputy Associate Director for Research, Division of Plasma Protein Therapeutics, FDA

Expression Optimization of an Antibody Fab Fragment in Escherichia coli with Non-Native Amino Acid (NNAA) Incorporated

Harun Rashid, PhD, Senior Principal Scientist, Molecular Technology, Ambrx

Expression Vector-Derived Heterogeneity in a Therapeutic IgG4 Monoclonal Antibody

Matthew Schenauer, PhD, Senior Research Scientist II, Gilead Sciences

Optimizing Gene Sequences for Improved Protein Expression in Industrial Microorganisms

Tomoshi Kameda, PhD, Senior Research Scientist, National Institute of Advanced Industrial Science and Technology

* The program is subject to change without notice, due to unforeseen reason.

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