Cambridge Healthtech Institute’s 9th Annual

Higher-Throughput Protein Production and Characterization

Analyzing & Improving Processes

January 23-24, 2020

Part of the Process Technologies & Purification pipeline

In CHI’s Higher-Throughput Protein Production and Characterization conference, HTP is explored in the quest to develop methods that ensure quality and translate to large scale much more quickly and efficiently than in the past. Automation, robotics, and liquid handlers will be discussed, along with developing small-scale models and multi-scale models that shed light on bioproduction, particularly for continuous processing. Case studies will be presented that illustrate how leaders in the field are integrating HTP approaches to reduce the time and effort needed to successfully analyze proteins, fine tune processes, and develop new classes of biological products.

Preliminary Agenda


KEYNOTE PRESENTATION: High-Throughput Generation of Protein Libraries for Early Stage Development of Novel Therapeutics

Renaud Vincentelli, PhD, Head, High-Throughput Protein Production, Structural Biology Core, Architecture et Fonction des Macromolécules Biologiques (AFMB), UMR, CNRS – Aix-Marseille University

From DNA to Protein in Under 24 Hours: A Rapid and High-Throughput Method to Produce Native Protein

Christopher Bahl, PhD, Head, Protein Design, Institute for Protein Innovation

High-Throughput Production of Antibodies Using Yeast and Mammalian Cells

Jürgen Nett, PhD, Director High-Throughput Expression, Adimab, LLC


Application of a High-Throughput Antibody Optimization Platform: From NGS-Supported Library Generation to High-Throughput Antibody Expression and Multi-Parameter Characterization of Large Variant Libraries

Ernst Weber, PhD, Antibody Lead Discovery and Optimization, Research & Development, Pharmaceuticals, Bayer AG

Platformization of Multi-Specific Protein Engineering III: Generating Large, Multiparametric Data Sets for Data Mining Through End-To-End Automated High-Throughput Engineering Workflows

Jörg Birkenfeld, PhD, Section Head, High Throughput Biologics, R&D Biologics Research / Protein Therapeutics, Sanofi-Aventis Deutschland GmbH

High-Throughput Cloning for Biomarker Discovery and Functional Genomics

Vel Murugan, PhD, MBA, Research Scientist, Virginia G. Piper Center for Personalized Diagnostics, The Biodesign Institute, Arizona State University


High-Throughput Production of Human Proteins for Structure/Function Analyses

Nicola Burgess-Brown, PhD, Principal Investigator, Nuffield Department of Medicine, SGC, University of Oxford

Using High-Throughput Physicochemical Testing and Biorelevant Assays in Formulation Development for Biotherapeutics

Sabine Eichling, PD, Senior Scientist II, Drug Product Development and Head, NBE Advanced Formulation Development, AbbVie Deutschland GmbH & Co. KG

A High-Throughput Approach for Screening Protein-Protein Interactions in Complex Biofluids Using Protein Engineering

Liviu Movileanu, PhD, Professor, Physics, and Biomedical and Chemical Engineering, Syracuse University

DNA Encoded Glycan Libraries as a Next-Generation Tool for Screening and Measuring Sugar Binding

Peng George Wang, PhD, Professor and Endowed Georgia Research Alliance Eminent Scholar, Chemistry, Georgia State University

* The program is subject to change without notice, due to unforeseen reason.

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