Cambridge Healthtech Institute’s Inaugural

Lead and Candidate Selection for Therapeutic Proteins

January 21-22, 2020

Part of the Protein Engineering & Development pipeline


The screenings and studies that comprise a company's lead and candidate selection funnel are an essential stage of biopharmaceutical R&D and good selections not only ensure that the best quality molecules are chosen for advancement, but that these match target profile for efficacy, safety and pharmacology. PepTalk's new Lead and Candidate Selection for Therapeutic Proteins meeting presents a wide range of strategies, models and technologies used for these evaluations, and considers the best practices in this field. Case studies from both large and small organizations will showcase the innovative ways organizations have employed these tools to help ensure rapid progression through subsequent development steps and the prospects for success in the clinic.


Coverage will include, but is not limited to:

  • Accelerating the timeline from target to lead/candidate
  • Best practices for emerging analytical techniques (machine learning, Cryo-EM, CRISPR, etc.)
  • Capture, format and curation of lead selection data
  • Case studies of decision matrixes – efficiency, quality of predictions, novel screening criteria
  • Considering alternatives that get to the same therapeutic goal
  • Disease models for efficacy prediction
  • Experimental validation of structural modeling and rational design
  • Immunogenicity prediction and mitigation
  • Improving the quality of developability prediction
  • PK screening and simulation of the in vivo fate of the drug
  • Retrospective analysis of B cell responses in hits


* The program is subject to change without notice, due to unforeseen reason.

2020 Conferences & Training Seminars