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Cambridge Healthtech Institute’s 7th Annual

Optimizing Expression Platforms

January 23-24, 2020

Part of the Biotherapeutic Expression & Production pipeline

 

The utilization of engineered therapeutic proteins for basic research, clinical diagnostics, and therapy continues to expand. Consequently, protein expression laboratory managers and researchers face challenges for efficient expression, production, and purification even while improving quantity and quality, plus minimizing time and cost. Transient protein production (TPP) has the advantage of speed and limited risk, while stable transfection – the longer and more complex process – has the advantage of being able to produce long-term expression of the biotherapeutic of interest. The rapidly increasing need for recombinant proteins necessitates further improvements in both technologies.

Cambridge Healthtech Institute’s 7th Annual Optimizing Expression Platforms conference convenes protein expression specialists who share experiences from their expression and production laboratories with process and platform differences, tradeoffs, and improvements for producing recombinant proteins.

 

Coverage will include, but is not limited to:                                        

  • Host Selection and Optimization
  • Transfection Optimization and Performance
  • Cell Culture Optimization and Monitoring
  • Automation of Cell Maintenance
  • Optimizing the Secretion of Recombinant Proteins
  • Improvements of Cytoplasmic Expression
  • Solubility and Protein Folding
  • Glycosylation and Other Posttranslational Modifications
  • Increasing Speed and Lowering Cost
  • Stable Expression vs. Transient Expression
  • Purification Process Development
  • Upstream and Downstream Scale-up
  • Development of Analytical Assays to Determine Identity, Purity, and Biological Activity
  • Establishing and Managing an Efficient Production Facility

 

* The program is subject to change without notice, due to unforeseen reason.







2020 Conferences & Training Seminars