Cambridge Healthtech Institute’s 11th Annual

Protein Aggregation and Emerging Analytical Tools

January 23-24, 2020

Part of the Formulation & Stability pipeline

The popular 11th Annual Protein Aggregation and Emerging Analytical Tools conference covers latest trends, challenges and solutions in understanding, characterization and mitigation of problems generated by protein aggregation in biopharmaceuticals. This conference will feature in-depth case studies, new and unpublished data and interactive discussions on immunogenicity of aggregates, mechanisms of aggregation, new tools for detection and quantitation of aggregates, and how the data is used in regulatory filings. It will also discuss mechanistic understanding of protein aggregation and present case studies on prevention of particle formation by engineering and formulation approaches, aggregation in ADCs, bispecifics, impact of aggregation on production, aggregates as a factor for immunogenicity, and approaches for improvement of biophysical properties of protein solutions.

We invite you to join with colleagues from around the world in this discussion of the key challenges and solutions in protein aggregation in biotherapeutics.

Preliminary Agenda


Understanding and Predicting Self-Association in High-Concentration Antibody Solutions – A Colloid Approach

Peter Schurtenberger, PhD, Professor, Department of Chemistry, Lund University

Estimating Solution Nonideality from Measured Values

Thomas Laue, PhD, Professor Emeritus, Biochemistry and Molecular Biology; Director, Biomolecular Interaction Technologies Center (BITC), University of New Hampshire


Thermodynamics Based Approach for Predicting Aggregation Propensity and Beneficial Solution Conditions in Antibody Formulations

Christoph Brandenbusch, PhD, Group Leader, Biochemical and Chemical Engineering, TU Dortmund

In silico Modeling and Novel High-Resolution Analytical Tools to Identify High-Concentration Molecular Hotspots

Reza Esfandiary, Associate Director, Early Stage Formulation Sciences, BioPharmaceutical Development, AstraZeneca

Discerning the Synergistic Effect of Hydrodynamic Flow and Interfaces on Protein Aggregation

Paolo Arosio, PhD, Professor, Biochemical Engineering, Department of Chemistry and Applied Biosciences, ETH Zurich

Computer Simulations of Aggregation of Proteins and Peptides

Andrzej Kloczkowski, PhD, Professor, Pediatrics, Nationwide Children's Hospital and The Ohio State University

FDS-AUC Analysis of mAb Nonideality and Self-Association in Serum and Formulation Solutions

John J. Correia, PhD, Professor, Department of Biochemistry, University of Mississippi Medical Center


Challenges in Characterization and Developability Assessments of Multispecific Antibodies

Melanie Fischer, PhD, Section Head Assays and Analytics, Biologics Research Germany – Protein Therapeutics, Sanofi-Aventis Deutschland GmbH

Fill/Finish Strategies to Prevent and Overcome Aggregation Challenges

Marcel Tigges, PhD, Associate Director, The Janssen Pharmaceutical Companies of Johnson & Johnson

* The program is subject to change without notice, due to unforeseen reason.

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