Precision medicine continues to progress immensely in the last decade and these successes have enabled the identification of therapeutic strategies more accurately for patients than ever. Our 5th Annual Precision Medicine conference program will once again bring together experts in the field to share their knowledge and approaches in moving precision medicine toward routine practice. We will showcase cutting edge technologies and workflow on how to implement precision medicine in clinical settings and not just research focus. We will examine the different approaches in phenotyping patients based on EMR data and other AI-driven technologies. Other diseases beyond oncology will also be discussed.

Final Agenda

Sunday, March 1

2:00 - 5:00 pm Afternoon Short Courses*

*Separate registration required

5:30 - 8:30 Dinner Short Courses*

*Separate registration required

Monday, March 2

8:00 - 11:00 am Morning Short Courses*

*Separate registration required

10:30 Conference Program Registration Open

CURRENT STATUS OF PRECISION HEALTH

11:45 Organizer’s Opening Remarks

Ngoc ‘Emily’ Le, PhD, Conference Producer, Cambridge Healthtech Institute

11:50 Chairperson’s Remarks

Ralph Snyderman, MD, Chancellor Emeritus, Duke University; Director, Duke Center for Personalized Health Care

11:55 FEATURED PRESENTATION: The Precision Health Care Revolution – From Now into the Future

Snyderman_Ralph2Ralph Snyderman, MD, Chancellor Emeritus, Duke University; Director, Duke Center for Personalized Health Care

Personalized, precision health is forging a transformation in care from its current focus on one-size-fits-all treatment for established diseases to a personalized, predictive approach that improves health, prevents disease, and treats it precisely when it occurs. This allows personalized care for each individual’s specific needs. This field is driven by the explosive development of capabilities stemming from genomic technologies, targeted therapies, digital and mobile health technologies, big data collection, artificial intelligence, and clinical awareness of personalized, proactive, patient-driven approaches to care. The harmonization of the new technologies with effective clinical application is a great challenge, but an even greater opportunity.

12:25 pm AI-Enabled Precision Medicine in Clinical Decision Support and Point-of-Care Diagnosis

Lungren_MatthewMatthew Lungren, MD, MPH, Associate Director, Stanford Center for Artificial Intelligence in Medicine and Imaging, Stanford Child Health Research Institute; Faculty Scholar; Assistant Professor of Radiology, Radiology, Stanford University, School of Medicine, Lucile Packard Children’s Hospital

Can machine learning help all clinicians achieve expert-level diagnosis and patient-specific risk predictions at the point of care? We will explore frame-shifting research that opens new approaches to care delivery in a precision medicine paradigm while also discussing some of the pitfalls and lessons-learned from our field-leading medical AI work at Stanford with partner institutions all over the world.

12:55 Session Break

thermofisherscientific_no_tagline 1:05 Luncheon Presentation I: Accelerate Assay Adoption by Partnering with a Proven Leader in Instrumentation

Andruss_BernardBernard Andruss, PhD SVP, Operations and Regulatory Affairs, Asuragen, Inc.

Searching for a platform partner to meet your assay commercialization needs?  Come learn about how working with Thermo Fisher Scientific, a proven leader in instrumentation, can accelerate test adoption in your target markets.  Leverage the strength of Thermo Fisher's nucleic acid extraction, PCR, qPCR, Capillary Electrophoresis, microarray and Next Generation Sequencing platforms. Partnership models include reagent rental agreements and private label options.

1:35 Luncheon Presentation II (Sponsorship Opportunity Available)

2:05 Session Break

PHENOTYPING PATIENTS USING ELECTRONIC HEALTH RECORDS AND GENOMIC DATA

2:20 Chairperson’s Remarks

Kenna R. Mills-Shaw, PhD, Executive Director, Khalifa Institute for Personalized Cancer Therapy, MD Anderson Cancer Center

2:25 Machine Learning for Identifying Phenotypes in Electronic Health Records

Ritchie_MarylynMarylyn D. Ritchie, PhD, Professor, Genetics; Director, Center for Translational Bioinformatics, Institute for Biomedical Informatics (IBI); Associate Director for Bioinformatics, Institute for Biomedical Informatics (IBI); Associate Director, Penn Center for Precision Medicine, University of Pennsylvania, Perelman School of Medicine

Comprehensive collections of phenotypic data can be used in more integrated ways to better subset or stratify patients based on the totality of his or her health information. Through applying machine learning to the rich phenotypic data of the EHR, these data can be mined to identify new and interesting patterns of disease expression and relationships. We have been exploring machine learning technologies for evaluating the phenomic landscape to improve our understanding of complex traits. These techniques show great promise for the future of precision medicine.

2:45 Electronic Health Records and Computable Phenotyping Strategies

Crawford_DanaDana C. Crawford, PhD, Associate Professor, Department of Population and Quantitative Health Sciences, Case Western Reserve University

Electronic health records capture individual-level data related to clinical care including medical history, diagnoses, medications, laboratory measures, and social history. While the recording of these data is intended for clinical care and billing, they can be repurposed for precision medicine research albeit with some limitations. In this session, strategies to access these data to extract research-grade variables will be discussed, including common rules-based approaches and more recent computable phenotyping approaches that leverage known genetic relationships to human diseases and traits.

3:05 Maximizing Genomics for Obtaining Clinically Relevant Information in Adult and Pediatric Cancers

Fernandes_HelenHelen Fernandes, PhD, Co-Director Genomic Oncology, Laboratory of Personalized Genomic Medicine, Columbia University Medical Center

Genomic tests for precision oncology range from interrogation of nucleic acids in single genes to whole exome and whole genome. Successful implementation of validated assays in a clinical setting is often determined by outcome measures. Selecting the appropriate test that provides information that is relevant to patient management in a time and cost-effective manner is essential for the viability of personalized genomics. In this session, we will discuss optimal utilization of hotspot panels, versus large targeted panels and whole exome sequencing. Case studies will be utilized to illustrate the efficacy of each panel in the management of adult and pediatric cancers.

3:25 Precision Cancer Medicine: Neither Silver Bullet nor an Illusion

Shaw_KennaKenna R. Mills-Shaw, PhD, Executive Director, Khalifa Institute for Personalized Cancer Therapy, MD Anderson Cancer Center

Precision oncology is neither an illusion nor is it a panacea. Precision oncology has routinely been utilized in subsets of specific molecularly defined tumors to elicit dramatic and sometimes durable responses. As novel drugs enter clinical trials based on emerging biological discoveries, implementation of precision oncology grows into an unmanageable feat without a highly integrated decision support platform that is both proactive, providing timely updates, as well as responsive to the changing clinical landscape. This talk will discuss how decision support can be a necessary transformative force for precision oncology, ultimately resulting in systematic improvements in clinical care and improvements in patient outcome. Read a recent article published in Diagnostics World

GuardantHealth_new 3:55 Presentation to be Announced

4:25 Refreshment Break and Transition to Plenary Keynote


PLENARY KEYNOTE SESSION

4:35 Welcome Remarks

Cindy Crowninshield, RDN, LDN, HHC, Executive Event Director, Cambridge Healthtech Institute

4:45 PLENARY KEYNOTE INTRODUCTION

Thomas Westerling-Bui, PhD, Senior Scientist, Regional Business Development, Aiforia

5:00 PLENARY KEYNOTE PRESENTATION: High-Performance Medicine

Eric Topol, MD, Founder and Director, Scripps Research Translational Institute (SRTI); Author, Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again

 

 

 

 

6:00 Grand Opening Reception in the Exhibit Hall with Poster Viewing, Speed Networking, Book Signing, and Meetup Group

7:30 End of Day

Tuesday, March 3

7:30 am Registration Open and Morning Coffee

FROM THE BEDSIDE TO THE PUBLIC: GENOMICS IN ACTION

8:00 Organizer’s Remarks

Ngoc ‘Emily’ Le, PhD, Conference Producer, Cambridge Healthtech Institute

8:05 Chairperson’s Remarks

Karl V. Voelkerding, MD, Professor, Pathology, University of Utah; Medical Director for Genomics and Bioinformatics, ARUP Laboratories

8:10 Genomic Approaches for Pediatric Oncology Testing

Larissa V. Furtado, MD, Medical Director, Molecular Pathology, Pathology, St. Jude Children’s Research Hospital

The biology of pediatric cancers is complex due to the diverse and primarily genetically driven features that reflect their unique cellular origins. Strategies to clinical genomic testing for childhood cancers should therefore include large-scale molecular profiling to account for these distinctive underlying driver mechanisms. This talk will review comprehensive genomic approaches and their value in the diagnosis and management of pediatric cancers.

8:40 Rapid Genomic Sequencing-Based Diagnosis in Critically Ill Newborns

Kingsmore_StephenStephen Kingsmore, MD, DSc, President/CEO, Rady Children’s Institute for Genomic Medicine

This presentation will describe how rapid genomic sequencing-based approaches coupled with advanced data analytics are being applied to yield molecular diagnoses in critically ill newborns suspected of having genetic disorders. Also discussed will be how these approaches are being collaboratively applied in a network of additional hospital centers in California through the Baby Bear project.

9:10 The All of Us Research Program: Advancing Precision Health for All

Lunn_MitchellMitchell R. Lunn, MD, MAS, FASN, Assistant Professor, Medicine; Co-Director, The PRIDE Study, Stanford University School of Medicine

NIH’s All of Us Research Program, launched nationally in May 2018, is working to build the largest, most diverse research resource of its kind to accelerate biomedical discoveries and advance precision medicine. The program aims to enroll one million or more participants across the country, with a special focus on engaging populations that are historically underrepresented in research. This presentation will provide an overview of the program, an update on its progress to date, and information about the data and tools that will be broadly accessible to researchers for a wide range of studies.

9:40 Refreshment Break in the Exhibit Hall with Poster Viewing, Speed Networking, Book Signing, and Meetup Group

DECODING DISEASES IN THE ERA OF PRECISION HEALTH USING AI AND MACHINE LEARNING

10:40 Chairperson’s Remarks

Keith L. Ligon, MD, PhD, Associate Professor, Pathology, Harvard Medical School; Associate Pathologist and Neuropathologist, Pathology; Director, DFCI Center for Patient Derived Models, Brigham and Women’s Hospital

10:45 Translating Ten Trillion Points of Data into Diagnostics, Therapies and New Insights in Health and Disease

Butte_AtulAtul Butte, MD, PhD, Priscilla Chan and Mark Zuckerberg Distinguished Professor; Director, Bakar Computational Health Sciences Institute, University of California, San Francisco; Chief Data Scientist, University of California Health (UC Health)

We build and apply tools that convert trillions of points of molecular, clinical, and epidemiological data – measured by researchers and clinicians over the past decade and now commonly termed “big data” – into diagnostics, therapeutics, and new insights into disease. Dr. Butte, a computer scientist and pediatrician, will highlight his center’s recent work on integrating electronic health records data across the entire University of California, and how analytics on this “real world data” can lead to new evidence for drug efficacy, new savings from better medication choices, and new methods to teach intelligence – real and artificial – to more precisely practice medicine.

11:15 Using Networks to Decode Cancer Risk

Quackenbush_JohnJohn Quackenbush, PhD, Professor and Chair, Biostatistics, Harvard TH Chan School of Public Health

Precision medicine is based on the idea that single mutations can inform our understanding of disease and response to therapy. But we know that cancer is multifactorial, with many genetic variants moderating disease and disease risk. By using network methods, we can better understand how and why cancer develops and assess disease risk.

11:45 Sponsored Presentation (Opportunity Available)

12:15 pm Session Break

12:20 LUNCHEON PRESENTATION I: A Modern Molecular LIMS Built for Precision Medicine

Hafez_NabilNabil Hafez, MS, Senior Director, Product Management, Precision Medicine, Sunquest Information Systems

With the advent of precision medicine, molecular labs are facing greater testing demand than ever before. Molecular diagnostics are complicated, rapidly changing, and subject to detailed regulatory auditing. Learn how modern labs are streamlining molecular testing, scaling for volume and growth, and mastering compliance with purpose-built LIMS technology.

12:50 Luncheon Presentation II (Sponsorship Opportunity Available)

1:20 Refreshment Break in the Exhibit Hall with Poster Viewing, Speed Networking, Book Signing, and Meetup Group

2:00 Breakout Discussions in the Exhibit Hall (please click here for details)

3:00 Transition to Keynote Session

KEYNOTE SESSION

3:15 Organizer’s Remarks

Christina Lingham, Executive Director, Conferences and Fellow, Cambridge Healthtech Institute

3:20 Keynote Introduction

3:35 What Does the New Era of Genomic Medicine Look Like? Effects on Patient Care, Therapeutics, and Diagnostics

20 years after the completion of the first draft of the Human Genome Project, there is compelling evidence of genomics delivering the rich promise of precision medicine. There have been major advances in the throughput and affordability of genome sequencing, enhanced tools for genome analysis and interpretation, new paradigms for therapeutics and strong signs of clinical benefit using genome editing. But major challenges remain. In this special plenary roundtable, three established pioneers of genomic medicine – David Haussler, Stephen Kingsmore, and Liz Worthey – offer their insights on the extraordinary advances in genomic medicine over the past 1-2 decades and share their hopes and concerns for the future of our field.

Davies_KevinModerator: Kevin Davies, PhD, Executive Editor, The CRISPR Journal, Mary Ann Liebert, Inc.


Kingsmore_StephenPanelists: Stephen Kingsmore, MD, DSc, President/CEO, Rady Children’s Institute for Genomic Medicine


Haussler_DavidDavid Haussler, PhD, Investigator, Howard Hughes Medical Institute; Distinguished Professor, Biomolecular Engineering, University of California, Santa Cruz; Scientific Director, UC Santa Cruz Genomics Institute; Scientific Co-Director, California Institute for Quantitative Biosciences (QB3)


Worthey_LizElizabeth Worthey, PhD, Director, Genomic Medicine, University of Alabama, Birmingham School of Medicine


4:50 Spring Fling Celebration in the Exhibit Hall with Poster Viewing, Speed Networking, Book Signing, and Meetup Group

6:00 End of Day

6:30 - 9:30 Dinner Short Courses*

*Separate registration required

Wednesday, March 4

6:45 am Registration Open

7:00 BREAKFAST PANEL DISCUSSION: The Time is NOW: Creating Meaningful Change for Women in the Workplace (Sponsorship Opportunity Available)

Toft_RobinModerator: Robin Toft, Author of WE CAN, The Executive Woman’s Guide to Career Advancement; Founder and Chairman, Toft Group Executive Search


Samuels_CamillePanelists: Camille Samuels, MBA, Partner, Venrock


Hastings_PaulPaul Hastings, President and CEO, Nkarta Therapeutics, Inc


Wright_TerryTeresa L. Wright, MD, Staff Physician, Medicine, San Francisco Veterans Administration


DELIVERING PRECISION MEDICINE TO PATIENTS

8:00 Organizer’s Remarks

Ngoc ‘Emily’ Le, PhD, Conference Producer, Cambridge Healthtech Institute

8:05 Chairperson’s Remarks

Albine Martin, PhD, Executive in Residence, Johns Hopkins University

8:10 PANEL DISCUSSION: Drivers and Barriers of Advancing Innovation to Patients

Martin_AlbineModerator: Albine Martin, PhD, Executive in Residence, Johns Hopkins University


Sheppard_ElizabethPanelists: Elizabeth Sheppard, MBA, Senior Director, Global Market Access, Roche Tissue Diagnostics, United States


Ibert_HiljaHilja Ibert, PhD, CEO, Gentian


Additional Panelists to be Announced

8:55 PANEL DISCUSSION: Coverage and Reimbursement of Advanced Diagnostics

As healthcare is transitioning from “sick” care to “well” care and shifting from fee-for-service to value-based models, it’s essential that we develop evidence to demonstrate the new value of the laboratory for optimized reimbursement.

Topics to be discussed:

  • Understand how to define and measure value using appropriate KPIs to help influence reimbursement policy.
  • Learn ways to survive financially as payment models shift and reimbursement is driven by outcomes and risk with potential upside depending upon the reimbursement model.
  • Explore key partnership opportunities that are aligned  with the changes in healthcare to help shape value.

Moderator: Khosrow R. Shotorbani, President, Executive Director, Project Santa Fe Foundation

Panelists: Gabriel Bien-Willner, MD, PhD, Medical Director, Moldx, Palmetto GBA

Kristine Bordenave, MD, FACP, Former Corporate Medical Director, Humana

Lon Castle, CMO, Molecular Genetics and Personalized Medicine, eviCore Healthcare

Shivang Doshi, Director, Boston Healthcare Associates, Inc.

 

 

9:40 Refreshment Break in the Exhibit Hall with Poster Viewing, Speed Networking, Book Signing, and Meetup Group

INDIVIDUALIZED HIGH-THROUGHPUT SCREENING FOR PRECISION MEDICINE

10:40 Functional Precision Medicine in Brain Tumors and Other Cancers

Ligon_KeithKeith L. Ligon, MD, PhD, Associate Professor, Pathology, Harvard Medical School; Associate Pathologist and Neuropathologist, Pathology; Director, DFCI Center for Patient Derived Models, Brigham and Women’s Hospital

We have developed large-scale cohorts of novel patient-derived cell lines (3D) and xenografts which represent the wide spectrum of phenotypes and genotypes seen in the diseases. We also developed large-scale pharmacogenomic screening approaches to prioritize the genotypes most responsive to such therapies and developed acute sensitivity assays based on novel biomarkers of mass and imaging to assess individual patient samples freshly derived from patients enrol-ling in clinical trials and standard of care therapy. Such acute sensitivity assays show reliable results for individual patients for both diagnosis and also represent novel approaches to genera-tion of early-phase human evaluation of novel drugs in clinical trials and can shorten the time frame of data generation and lower costs for clinical trials in these diseases.

11:10 Leveraging Tumor Organoids for Functional Precision Medicine Applications

Soragni_AliceAlice Soragni, PhD, Assistant Professor, Orthopaedic Surgery, University of California Los Angeles

We have established a pipeline to process clinical samples obtained from tumor resection sur-geries, develop tumor organoid models with success rates above 90% and perform high-throughput drug screenings. We take advantage of our ring approach that uses a modified ge-ometry to facilitate and automate changing media, adding drugs and performing assays (Phan et al, 2019). Our methodology allows us to successfully obtain and perform large drug screenings for various tumors, including low-grade tumors or heavily pre-treated tumors, which are typi-cally refractory to grow in immunocompromised mice as patient-derived xenografts.

11:40 A Hybrid Genomic/Phenomic Approach to Personalizing Cancer Therapies

Reid_CliffordClifford Reid, PhD, Founder and CEO, Travera

To make the wealth of genomic information broadly useful for patient care, we propose a new approach to identifying effective therapies for patients who have driver mutations in cancer genes but no FDA-approved matching therapies. First, we use genomics to identify a set of candidate drugs though cancer pathway analysis: we identify which pathways the patient’s mutations affect, and then identify the existing FDA-approved drugs that work on those pathways. Second, we use phenotypic testing to identify the subset of the candidate drugs that are most likely to be effective in the patient: we test each candidate drug ex vivo against the patient’s live cancer cells and identify the high-response drugs.

12:10 pm Sponsored Presentation (Opportunity Available)

12:40 Session Break

NeoGenomics 12:50 Precision Health Luncheon Presentation to be Announced

1:20 Refreshment Break in the Exhibit Hall with Last Chance Poster Viewing, Speed Networking, Book Signing, and Meetup Group

NANO AND MICROFLUIDIC SYSTEMS FOR PRECISION MEDICINE APPLICATIONS

2:00 Chairperson’s Remarks

Hsueh-Chia Chang, PhD, Bayer Corporation Professor of Chemical Engineering, Chemical and Biomolecular Engineering, University of Notre Dame

2:05 Diagnosing Disease with Rare Circulating EVs: Finding Heterogeneous, Nanoscale Needles in a Nanoscale Haystack

Issadore_DavidDavid A. Issadore, PhD, Assistant Professor, Bioengineering & Electrical & Systems Engineering, University of Pennsylvania

We developed a multichannel nanofluidic system to analyze crude clinical samples. Using this platform, we isolated EVs, profile the RNA cargo inside of these EVs, and apply a machine learning algorithm to generate predictive panels that could provide useful diagnostics for applications in traumatic brain injury and pancreatic cancer using both murine models and clinical samples.

2:35 Isolation/Fractionation of Blood Exosomes and Profiling of Exosomal miRNA for Precision Medicine Application

Chang_Hsueh_ChiaHsueh-Chia Chang, PhD, Bayer Corporation Professor of Chemical Engineering, Chemical and Biomolecular Engineering, University of Notre Dame

We present two nanofluidic technologies for high-yield and high-throughput fractionation of nanoparticles carriers in blood, like exosomes, lipoproteins and ribonucleoproteins, which carry most of the extracellular RNAs. Both use asymmetric nanopore membranes (ANM) that are asymmetrically etched from ion-track membranes. ANM allows high throughput (>5 ml/hour) isolation of nanoparticles of specific size range by nanofiltration, without lysing or coalescence and with high purity (low protein content). It also allows high-yield nano-magnetic bead capture of particles with specific surface antigens.

3:05 Precision Microfluidic Medicine: From Single Cell Analysis and to Single Cell Engineering for Cell-Based Theranostics

lee_abrahamAbraham “Abe” P. Lee, Professor, Biomedical Engineering; Professor, Mechanical & Aerospace Engineering; Director, NSF I/UCRC, University of California at Irvine

We present a microfluidic trapping array which is able to rapidly and deterministically trap single cells in highly-packed microwells. As the single-cell trapping efficiency is determined by the channel design instead of the flow rate, this trapping array can be coupled with different microfluidic sample processing units with different flow rates for various single-cell analyses.

3:35 Close of Conference


* The program is subject to change without notice, due to unforeseen reason.

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Update History
2020/02/12
Sponsor updated
2020/01/17
Agenda,Speaker,Sponsor updated
2019/12/20
Agenda,Sponsor updated
2019/12/06
Speaker,Sponsor updated
2019/11/22
Sponsor updated
2019/11/07
Sponsor updated
2019/10/31
Agenda,Speaker,Sponsor updated
2019/09/18
Agenda,Speaker,Sponsor updated


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