Cambridge Healthtech Institute’s 8th Annual

Biophysical Methods

Characterizing and Optimizing the Physical Properties of Proteins in the Research and Development of Next-Generation Biologics

May 6-7, 2020


Biophysical analytical methods are now playing an increasingly important role in the discovery and development of next-generation biotherapeutics, and these tools are applied for developability evaluation, structural characterization, understanding aggregation, and as important inputs at different stages of R&D. New informatics and instruments are increasingly allowing these methods to be used in a quantitative, rather than qualitative way – and biophysical studies now play a key role in regulatory filings. The PEGS Biophysical Methods conference brings together an international audience of protein scientists and analytical specialists to explore the latest technologies and methods for problem-solving in this dynamic field.

Preliminary Agenda

AUTOMATION, MODELING AND HIGH-THROUGHPUT ANALYSIS

Discovery Developability Workflow to Utilize Machine Learning Algorithms for Biologics Optimization

Marc Bailly, PhD, Associate Principal Scientist, Merck

KEYNOTE PRESENTATION: Machine Learning Applications for Analysis of Process-Induced Protein Aggregates

Theodore W. Randolph, PhD, Professor, Chemical and Biological Engineering, University of Colorado

Machine Learning for Sub-Visible Particle Classification

Bjorn Boll, PhD, Head, Particle Lab and Higher Order Structure Protein Analytics, Physical Chemical Analytics, Novartis Pharma AG, Switzerland

High-Throughput Methods for Protein Biophysics and Protein Design

Gabriel J. Rocklin, PhD, Assistant Professor, Pharmacology, Northwestern University

Automating Protein A through Tryptic Digest LC-MS/MS for Looking at Post-Translational Modifications on mAbs and Multi-Specifics

Stephen D'Eri, Scientist, Sanofi

ADVANCES IN CORE TECHNOLOGIES

Emerging Applications for Rapid Surface Plasmon Resonance (SPR) Analysis

Diana Pippig, PhD, Senior Scientist and Team Lead, Functional Characterization, Roche, Germany

Utilizing High-Throughput Differential Scanning Fluorimetry (DSF) to Inform Protein Engineering Decisions

Andrew Urick, PhD, Senior Scientist, AbbVie

EMERGING METHODS AND INSTRUMENTS

Membrane Mimetic FACS to Facilitate Antibody Screening

Christy Thomson, PhD, Senior Scientist, Research, Amgen

Combining Experimental and Computational Methods to Identify Antibody Variants with Drug-Like Biophysical Properties

Peter M. Tessier, PhD, Professor, Pharmaceutical Sciences and Chemical Engineering, University of Michigan

NEW APPLICATIONS FOR MASS SPECTROMETRY

Gas-Phase Structural Biology: New Tools for the Rapid Assessment of Protein Sequence, Structure and Stability

Brandon Ruotolo, PhD, Professor, Chemistry, University of Michigan

MS for Characterization and Profiling Assays

Benjamin Walters, PhD, Scientist, Biochemistry and Cellular Pharmacology, Genentech

HDX-MS for Structural Characterization of Therapeutics and Targets

John Kelly, PhD, Senior Research Officer, National Research Council Canada



* The program is subject to change without notice, due to unforeseen reason.

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Update History
2019/11/25
Sponsor updated



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