Cambridge Healthtech Institute’s 6th Annual

Protein Expression System Engineering

Gene to Cell Line

May 7-8, 2020

CHI’s 6th Annual Protein Expression System Engineering conference examines the functioning of the cellular machinery harnessed during protein biosynthesis, and how to engineer hosts to efficiently express a protein of interest. The intricate steps required to achieve properly folded protein will be discussed, including verification and sequence analysis of the gene, codon optimization, vector construction, selecting and optimizing a clone, and selecting a host system. In addition, engineering host cells to sustain expression for longer time periods will be discussed, along with overcoming cellular stress response to produce and secrete functionally active recombinant proteins.

Preliminary Agenda



Joshua LaBaer, MD, PhD, Executive Director & Professor, Molecular Sciences, BioDesign Institute, Arizona State University


Product Quality Control Strategy Development for Non-mAb Complex Modalities by Using Combinatorial Cell Engineering and OMICS Screening Tools

Zhimei Du, PhD, Director, Process Development, Merck and Co., Inc.


PERSIA for Direct Fluorescence Measurements of Transcription, Translation, and Enzyme Activity in Cell-Free Systems

Peter Carr, PhD, Synthetic Biologist, Lincoln Laboratory’s Bioengineering Systems and Technologies Group, Massachusetts Institute of Technology (MIT)


Codon and Codon-Pair Usage Tables (CoCoPUTs): Facilitating Genetic Variation Analyses and Recombinant Gene Design

Chava Kimchi-Sarfaty, PhD, Deputy Associate Director for Research, Office of Tissues and Advanced Therapies, CBER, FDA


Transposon-Encoded CRISPR-Cas Systems Direct RNA Guided DNA Integration

Samuel H. Sternberg, PhD, Assistant Professor, Biochemistry and Molecular Biophysics, Columbia University


Driving Biological Discovery: An Expanding Toolkit for Affinity Proteomics

John LaCava, PhD, Group Leader, Laboratory of Macromolecules and Interactomes, European Research Institute for the Biology of Ageing, University Medical Center Groningen


Exploitation of a Ribosomal Protein Mutation to Enhance Recombinant Protein Production

Kim De Keersmaecker, PhD, Research Professor, Oncology – Laboratory for Disease Mechanisms in Cancer, Katholieke Universiteit Leuven


Application of Multi-Omics Analyses to Guide Rational Process Development for Recombinant Protein Expression

Yizhou Zhou, PhD, Scientist II, Cell Line Development, Biogen


The Development of Advanced Synthetic Biology Tools to Accelerate CHO Cell Line Engineering

William C.W. Chen, MD, PhD, Research Scientist, Massachusetts Institute of Technology (MIT)


Applying Omics/NGS Tools to Characterize CHO Cell Line Clonality, Transcript Variants and Stability

Fides Lay, PhD, Experimental Scientist and Genomic Data Analyst, Cancer & Stem Cell Biologist, Amgen, Inc.


Multi-Omics Analysis of CHO Cell Lines Reveals Differences in Energy Metabolism and ER Stress

Amr S. Ali, PhD, Scientist, Technical Development, Biogen



* The program is subject to change without notice, due to unforeseen reason.

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