Cambridge Healthtech Institute’s 10th Annual

Optimizing Protein Expression

Enhancing Expression Systems

May 6-7, 2020

Expression of heterologous proteins presents many challenges, and understanding expression systems is key. The 10th Annual Optimizing Protein Expression conference delves into protein expression by examining and enhancing expression systems, including CHO, and other mammalian systems, E. coli, yeast, and baculovirus. What is the best expression system for expressing your protein of choice? Ease and cost of scale-up must be considered to ensure successful bottom-line results. Experts will share case studies and disclose data, while divulging details of expression systems’ underlying mechanisms. Comparing and contrasting systems will also be featured to increase understanding in the quest for greater productivity.

Preliminary Agenda


Strategies for Enhancing Protein Expression

Catherine Owczarek, PhD, Director, Recombinant Proteins, CSL Limited

Begin with the End in Mind: Seamless Transitioning of Novel Biologics from RES to DEV and Beyond

Ingo Gorr, PhD, Director and Head, Early Stage Bioprocess Development (USP&DSP), Boehringer Ingelheim Pharma GmbH & Co. KG

Leveraging the Benefits of Re-Coded Organisms to Access Homogeneous Post-Translationally Modified Proteins

Richard Cooley, PhD, Assistant Professor, Biochemistry and Biophysics, Oregon State University

Recombinant Protein Production Strategies for Multi-Protein Complexes in Drug Discovery

Saleha Patel, PhD, Senior Research Scientist, Protein Science, Discovery Biology, AstraZeneca

How to Design a Cost-Efficient Refolding Process for Biotherapeutic Proteins

Monique Janowski-Egler, PhD, Head of USP Development, BioProcess Development, Wacker Bio


The MultiBac System: A Perspective

Imre Berger, PhD, Director, Max Planck Centre for Minimal Biology, the University of Bristol

Identifying Parameters to Improve the Reproducibility of Transient Gene Expression in High Five Cells

Joop Van den Heuvel, PhD, Research Group Leader, Recombinant Protein Expression, Helmholtz Center for Infection Research


Large-Scale Synthetic Human Phosphoproteomes to Decode Novel Protein-Protein Interaction Networks in E. coli

Jesse Rinehart, PhD, Associate Professor, Cellular & Molecular Physiology, Systems Biology Institute, Yale University School of Medicine

Continuous Production with E. coli – USP Concepts and Strategies

Gerald Striedner, PhD, Associate Professor, University of Natural Resources and Life Sciences, Vienna (BOKU)

Overcoming Limitations of Conventional Tag Systems – Strep-Tactin® XT Applications

Dennis Karthaus, MSc, Director Protein Products & Assays, IBA Lifesciences


CHO Clonal Expression Stability and Sub-Clonal Population Heterogeneity

Theodore Peters, PhD, Senior Scientist, Cell Line Development Group, Seattle Genetics, Inc.


Novel engineered CHO DG44 Host Cell Line

Hussain Nuruddin Dahodwala, PhD, Scientist, Delaware Biotechnology Institute, University of Delaware



* The program is subject to change without notice, due to unforeseen reason.

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