Cambridge Healthtech Institute’s 2nd Annual

Encoded Libraries for Small Molecule Discovery

Expanding Chemical Space for New Drug Leads

April 15-16, 2020

DNA-encoded libraries (DELs) exploit chemical synthesis to create large numbers of compounds that can be simply and rapidly screened based on affinity-binding. DEL innovations have expanded the range of potential chemical compounds that can be screened for new drug development, thus creating drug leads better suited for newer targets such as intracellular protein complexes. However, while compound hits arising from DEL screens are typically bigger and more potent, they are often harder for the medicinal chemist to work with. Another challenge is how to integrate DEL applications into the drug discovery process. Cambridge Healthtech Institute’s 2nd Annual Encoded Libraries for Small Molecule Discovery conference (refocused from last year’s Directed Evolution conference) convenes early drug discovery scientists to discuss these challenges and more such as which targets are best suited for DEL approaches, best ways to screen the libraries, hit selection and methods for obtaining good quality starting point for medicinal chemistry optimization campaigns.

Preliminary Agenda


A Solution Phase Platform to Characterize Chemical Reaction Compatibility with DNA-Encoded Chemical Library Synthesis

Anokha Ratnayake, PhD, Principal Scientist, Applied Synthesis Technologies, DNA Encoded Library Technology (DELT) Group, Pfizer

Target Class-Focused DEL Libraries

Raphael Franzini, PhD, Assistant Professor, Medicinal Chemistry, University of Utah

Dual-Display DEL Technology and Beyond 

Joerg Scheuermann, PhD, Senior Lecturer, Chemistry & Applied Biosciences, ETH Zurich


Methods for Estimating Affinity from DEL Primary Selection Data

Justin Hall, PhD, Principal Scientist, Structural Biology & Biophysics, Pfizer

Advances in Activity-Based Screening of DNA-Encoded Libraries

Brian Paegel, PhD, Associate Professor, Department of Chemistry, Department of Molecular Medicine, Scripps Research

Talk Title to be Announced

Dean Brown, PhD, Director, External Chemistry, Hit Discovery, Discovery Sciences, IMED Biotech Unit, AstraZeneca

Encoded Library Technologies as Integrated Lead-Finding Platforms for Drug Discovery

Jonas Schaefer, PhD, Laboratory Head, Encoded Library Technologies, Novartis Institutes for Biomedical Research, Chemical Biology & Therapeutics (CBT), Novartis Pharma AG

DEL-Enabled Discovery of Novel MoA and Structurally Unique IDO1 Inhibitors

Bing Xia, PhD, NCE Encoded Library Technologies, RD Medical Science & Technology, GlaxoSmithKline, Boston

* The program is subject to change without notice, due to unforeseen reason.

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