Cambridge Healthtech Institute’s 12th Annual

Optimizing Cell Line Development

Enhancing Expression

August 27-28, 2020


As the biopharma field becomes increasingly more complex, engineering cell lines continues to be a foundation for developing biologics. This foundation draws from emerging research and breakthrough strategies to achieve cell lines that accomplish project goals quickly and inexpensively. The Optimizing Cell Line Development conference brings together experts who will share how to best optimize codons, construct vectors, and select and engineer clones and host systems, while maintaining stability and consistency. The conference will also focus on automation, high-throughput, genomic research, glycoengineering, systems biology, and pathway delineation.


Coverage will include, but is not limited to:


  • Gene expression/expression levels
  • Genomic research
  • Glycoengineering
  • Trends in industrial cell line development, such as CRISPR
  • Codon optimization
  • Vector construction
  • Clone selection & optimization
  • Host system selection & use
  • Cell line selection
  • Cell line attributes
  • High producer cell lines/industrial use
  • Synthetic biology
  • Regulatory perspectives on new technologies
  • Systems biology
  • Metabolomics
  • Hurdles for introducing new technologies
  • Sequencing the CHO genome
  • Transcriptomic data
  • Predictive modeling
  • Identifying the best hosts
  • Understanding hosts to control phenotypes
  • Engineering hosts
  • Designing a cell line for biosimilars
  • Arrays/microarrays
  • Process conditions & robustness
  • Developing new cell lines
  • Cell growth
  • Stability
  • Productivity
  • Reproducibility
  • Quality
  • Scalability
  • Cell line serviceability through late-stage product development
  • Protocols & case studies


* The program is subject to change without notice, due to unforeseen reason.

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